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. 1976 Sep;52(611):598–602. doi: 10.1136/pgmj.52.611.598

Ethylene glycol poisoning

J A Vale, B Widdop, N H Bluett
PMCID: PMC2495900  PMID: 981106

Abstract

Although an uncommon cause of death in Great Britain, ethylene glycol poisoning is potentially serious in that renal and cardiopulmonary failure and central nervous system dysfunction can occur when doses of the order of 100 ml or more are ingested. A case is described in which a child who swallowed approximately 100 ml of ethylene glycol was treated by prolonged peritoneal dialysis. In addition, measures were taken to correct a marked acidosis. Substantial amounts of ethylene glycol were removed by the dialysis fluid and the child made a complete physical and mental recovery.

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Selected References

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  1. Aquino H. C., Leonard C. D. Ethylene glycol poisoning: report of three cases. J Ky Med Assoc. 1972 Jun;70(6):463–465. [PubMed] [Google Scholar]
  2. BERMAN L. B., SCHREINER G. E., FEYS J. The nephrotoxic lesion of ethylene glycol. Ann Intern Med. 1957 Mar;46(3):611–619. doi: 10.7326/0003-4819-46-3-611. [DOI] [PubMed] [Google Scholar]
  3. Bachmann E., Golberg L. Reappraisal of the toxicology of ethylene glycol. 3. Mitochondrial effects. Food Cosmet Toxicol. 1971 Feb;9(1):39–55. doi: 10.1016/s0015-6264(71)80115-3. [DOI] [PubMed] [Google Scholar]
  4. Bove K. E. Ethylene glycol toxicity. Am J Clin Pathol. 1966 Jan;45(1):46–50. doi: 10.1093/ajcp/45.1.46. [DOI] [PubMed] [Google Scholar]
  5. Bowie M. D., McKenzie D. Diethylene glycol poisoning in children. S Afr Med J. 1972 Jul 1;46(27):931–934. [PubMed] [Google Scholar]
  6. Collins J. M., Hennes D. M., Holzgang C. R., Gourley R. T., Porter G. A. Recovery after prolonged oliguria due to ethylene glycol intoxication. The prognostic value of serial, percutaneous renal biopsy. Arch Intern Med. 1970 Jun;125(6):1059–1062. [PubMed] [Google Scholar]
  7. Gallyas F., Járay J., Csata S. Acute renal failure following ethyleneglycol poisoning. Report of three successfully treated cases. Acta Chir Acad Sci Hung. 1971;12(3):225–228. [PubMed] [Google Scholar]
  8. Gutman R. A., Hamon C. B., Striker G. E. Recovery after prolonged oliguria. Arch Intern Med. 1970 Nov;126(5):914–915. [PubMed] [Google Scholar]
  9. HAGGERY R. J. Toxic hazards. Deaths from permanent antifreeze ingestion. N Engl J Med. 1959 Dec 17;261:1296–1297. doi: 10.1056/NEJM195912172612514. [DOI] [PubMed] [Google Scholar]
  10. Hagstam K. E., Ingvar D. H., Paatela M., Tallqvist H. Ethylene-glycol poisoning treated by haemodialysis. Acta Med Scand. 1965 Nov;178(5):599–606. doi: 10.1111/j.0954-6820.1965.tb04308.x. [DOI] [PubMed] [Google Scholar]
  11. Jofre de Breyer I. J., Ortiz A., Soehring K. The effects of aldehydes on serotonin metabolism in rat liver slices. Pharmacology. 1970;3(2):85–90. doi: 10.1159/000136066. [DOI] [PubMed] [Google Scholar]
  12. KAHN H. S., BROTCHNER R. J. A recovery from ethylene glycol (anti-freeze) intoxication; a case of survival and two fatalities from ethylene glycol including autopsy findings. Ann Intern Med. 1950 Feb;32(2):284–294. doi: 10.7326/0003-4819-32-2-284. [DOI] [PubMed] [Google Scholar]
  13. KUN E. A study on the metabolism of glyoxal in vitro. J Biol Chem. 1952 Feb;194(2):603–611. [PubMed] [Google Scholar]
  14. Klamerth O. L. Influence of glyoxal on cell function. Biochim Biophys Acta. 1968 Jan 29;155(1):271–279. doi: 10.1016/0005-2787(68)90356-0. [DOI] [PubMed] [Google Scholar]
  15. LEVY R. I. Renal failure secondary to ethylene glycol intoxication. JAMA. 1960 Jul 16;173:1210–1213. doi: 10.1001/jama.1960.03020290036007. [DOI] [PubMed] [Google Scholar]
  16. Laborit H., Baron C., London A., Olympie J. Activité nerveuse centrale et pharmacologie générale comparée du glyoxylate, du glycolate et du glycolaldéhyde. Agressologie. 1971;12(3):187–211. [PubMed] [Google Scholar]
  17. Lamothe C., Thuret F., Laborit H. Action de l'acide glyoxylique, de l'acide glycolique et du glycoaldéhyde, in vivo et in vitro, sur quelques étapes du métabolisme énergétique de coupes de cortex cérébral, de foie, et de myocarde de rat. Agressologie. 1971;12(3):233–239. [PubMed] [Google Scholar]
  18. Lyon E. S., Borden T. A., Vermeulen C. W. Experimental oxalate lithiasis produced with ethylene glycol. Invest Urol. 1966 Sep;4(2):143–151. [PubMed] [Google Scholar]
  19. McChesney E. W., Golberg L., Parekh C. K., Russell J. C. Reappraisal of the toxicology of ethylene glycol. II. Metabolism studies in laboratory animals. Food Cosmet Toxicol. 1971 Feb;9(1):21–38. doi: 10.1016/s0015-6264(71)80114-1. [DOI] [PubMed] [Google Scholar]
  20. Oliva P. B. Lactic acidosis. Am J Med. 1970 Feb;48(2):209–225. doi: 10.1016/0002-9343(70)90117-8. [DOI] [PubMed] [Google Scholar]
  21. Parry M. F., Wallach R. Ethylene glycol poisoning. Am J Med. 1974 Jul;57(1):143–150. doi: 10.1016/0002-9343(74)90780-3. [DOI] [PubMed] [Google Scholar]
  22. Seeff L. B., Hendler E. D., Hosten A. O., Shalhoub R. J. Ethylene glycol poisoning. Survival after ingestion of 400 ml. with 42 days of oliguria and 17 days of coma. Med Ann Dist Columbia. 1970 Jan;39(1):31–36. [PubMed] [Google Scholar]
  23. Underwood F., Bennett W. M. Ethylene glycol intoxication. Prevention of renal failure by aggressive management. JAMA. 1973 Dec 17;226(12):1453–1454. doi: 10.1001/jama.226.12.1453. [DOI] [PubMed] [Google Scholar]
  24. VONWARTBURG J. P., BETHUNE J. L., VALLEE B. L. HUMAN LIVER--ALCOHOL DEHYDROGENASE. KINETIC AND PHYSICOCHEMICAL PROPERTIES. Biochemistry. 1964 Nov;3:1775–1782. doi: 10.1021/bi00899a033. [DOI] [PubMed] [Google Scholar]
  25. Wacker W. E., Haynes H., Druyan R., Fisher W., Coleman J. E. Treatment of ethylene glycol poisoning with ethyl alcohol. JAMA. 1965 Dec 13;194(11):1231–1233. [PubMed] [Google Scholar]
  26. Walls J., Morley A. R., Kerr D. N. Primary hyperoxaluria in adult siblings: with some observations on the role of regular haemodialysis therapy. Br J Urol. 1969 Oct;41(5):546–553. doi: 10.1111/j.1464-410x.1969.tb09960.x. [DOI] [PubMed] [Google Scholar]
  27. Zarembski P. M., Hodgkinson A. The fluorimetric determination of oxalic acid in blood and other biological materials. Biochem J. 1965 Sep;96(3):717–721. doi: 10.1042/bj0960717. [DOI] [PMC free article] [PubMed] [Google Scholar]

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