Skip to main content
NCBI home page
Postgraduate Medical Journal logoLink to Postgraduate Medical Journal
. 1974 Dec;50(590):755–758. doi: 10.1136/pgmj.50.590.755

Comparative clinical trial of diazepam with other conventional drugs in tetanus

Nalini T Vassa, V H Yajnik, K R Joshi, H V Doshi, S S Shah, S H Patel
PMCID: PMC2495997  PMID: 4619836

Abstract

Results of therapeutic trial of diazepam in tetanus are presented. The trial included 200 cases of tetanus—167 non-neonates and thirty-three neonates. The patients were divided into two groups and were matched as regards age, sex and severity of the disease. The cases of group I received standard treatment while the cases of group II received diazepam in addition. Over-all mortality in group I was 54% and in group II, 26%. The results were statistically significant in non-neonates and in severe degree of tetanus. The drug was well tolerated and side effects were not observed.

Full text

PDF
755

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arrigo A., Jann G., Tonali P. Some aspects of the action of valium and of librium on the electrical activity of the rabbit brain. Arch Int Pharmacodyn Ther. 1965 Apr;154(2):364–373. [PubMed] [Google Scholar]
  2. BRADLEY P. B., KEY B. J. The effect of drugs on arousal responses produced by electrical stimulation of the reticular formation of the brain. Electroencephalogr Clin Neurophysiol. 1958 Feb;10(1):97–110. doi: 10.1016/0013-4694(58)90107-x. [DOI] [PubMed] [Google Scholar]
  3. BROWN B. B., WERNER H. W. Pharmacologic studies on a new central stimulant, alpha-(2-piperidyl) benzhydrol hydrochloride (MRD-108). J Pharmacol Exp Ther. 1954 Feb;110(2):180–187. [PubMed] [Google Scholar]
  4. Das A. K., Gupta R. K., De S. Diazepam in tetanus. J Indian Med Assoc. 1967 Aug 1;49(3):130–132. [PubMed] [Google Scholar]
  5. Femi-Pearse D. Experience with diazepam in tetanus. Br Med J. 1966 Oct 8;2(5518):862–865. doi: 10.1136/bmj.2.5518.862. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Grewal R. S., Kaul C. L. Adrenaline reversal by CIBA 1002-Go. Eur J Pharmacol. 1969 Jan;5(2):153–160. doi: 10.1016/0014-2999(69)90023-5. [DOI] [PubMed] [Google Scholar]
  7. HENDRICKSE R. G., SHERMAN P. M. THERAPEUTIC TRIAL OF DIAZEPAM IN TETANUS. Lancet. 1965 Apr 3;1(7388):737–738. doi: 10.1016/s0140-6736(65)92094-5. [DOI] [PubMed] [Google Scholar]
  8. HERNANDEZ PEON R., ROJAS RAMIREZ J. A., O'FLAHERTY J. J., MAZZUCHELLI O'FLAHERTY A. L. AN EXPERIMENTAL STUDY OF THE ANTICONVULSIVE AND RELAXANT ACTIONS OF VALIUM. Int J Neuropharmacol. 1964 Sep;3:405–412. doi: 10.1016/0028-3908(64)90070-x. [DOI] [PubMed] [Google Scholar]
  9. Hendrickse R. G., Sherman P. M. Tetanus in childhood: report of a therapeutic trial of diazepam. Br Med J. 1966 Oct 8;2(5518):860–862. doi: 10.1136/bmj.2.5518.860. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. LAHA P. N., VAISHYA P. D. TETANUS; A STUDY OF 1,000 CASES. J Indian Med Assoc. 1965 Apr 16;44:422–436. [PubMed] [Google Scholar]
  11. PATEL J. C., JOAG G. G. Grading of tetanus to evaluate prognosis. Indian J Med Sci. 1959 Oct;13:834–840. [PubMed] [Google Scholar]
  12. RANDALL L. O., HEISE G. A., SCHALLEK W., BAGDON R. E., BANZIGER R., BORIS A., MOE R. A., ABRAMS W. B. Pharmacological and clinical studies on Valium (T.M.) a new psychotherapeutic agent of the benzodiazepine class. Curr Ther Res Clin Exp. 1961 Sep;3:405–425. [PubMed] [Google Scholar]
  13. WEINBERG W. A. CONTROL OF THE NEUROMUSCULAR AND CONVULSIVE MANIFESTATIONS OF SEVERE SYSTEMIC TETANUS: CASE REPORT WITH A NEW DRUG, VALIUM (DIAZEPAM). Clin Pediatr (Phila) 1964 Apr;3:226–228. doi: 10.1177/000992286400300407. [DOI] [PubMed] [Google Scholar]

Articles from Postgraduate Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES