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. 1975 Nov;51(601):795–800. doi: 10.1136/pgmj.51.601.795

The influence of nutritional factors on lead absorption

D Barltrop, H E Khoo
PMCID: PMC2496130  PMID: 1208288

Abstract

The nutritional factors which affect lead absorption have been studied. Synthetic diets of known composition were compounded to contain 0·075% Pb as PbCl2 labelled with 203Pb. Rats were exposed to lead for periods of 48 hr. The dietary intake was then measured and the absorption of lead determined by means of a whole-body counter. Lead absorption was increased by high fat, low mineral, low protein and high protein diets but was decreased by high mineral diet. Low fat, low fibre, high fibre, low vitamin and high vitamin diets had no effects on lead absorption.

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Selected References

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  1. Barltrop D., Meek F. Absorption of different lead compounds. Postgrad Med J. 1975 Nov;51(601):805–809. doi: 10.1136/pgmj.51.601.805. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Barry P. S., Mossman D. B. Lead concentrations in human tissues. Br J Ind Med. 1970 Oct;27(4):339–351. doi: 10.1136/oem.27.4.339. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Carr T. E., Nolan J., Duraković A. Effect of alginate on the absorption and excretion of 203Pb in rats fed milk and normal diets. Nature. 1969 Dec 13;224(5224):1115–1115. doi: 10.1038/2241115a0. [DOI] [PubMed] [Google Scholar]
  4. Forbes G. B., Reina J. C. Effect of age on gastrointestinal absorption (Fe, Sr, Pb) in the rat. J Nutr. 1972 May;102(5):647–652. doi: 10.1093/jn/102.5.647. [DOI] [PubMed] [Google Scholar]
  5. Gontzea I., Sutzesco P., Dumitrache S., Bistriceanu E. Recheches sur la rôle de l'apport protéique du les moyens de défense de l'organisme envers quelques toxiques chimiques. Arch Mal Prof. 1970 Sep;31(9):471–480. [PubMed] [Google Scholar]
  6. Harrison G. E., Carr T. E., Sutton A., Humphreys E. R., Rundo J. Effect of alginate on the absorption of lead in man. Nature. 1969 Dec 13;224(5224):1115–1116. doi: 10.1038/2241115b0. [DOI] [PubMed] [Google Scholar]
  7. Kello D., Kostial K. The effect of milk diet on lead metabolism in rats. Environ Res. 1973 Sep;6(3):355–360. doi: 10.1016/0013-9351(73)90048-0. [DOI] [PubMed] [Google Scholar]
  8. Kostial K., Simonović I., Pisonić M. Lead absorption from the intestine in newborn rats. Nature. 1971 Oct 22;233(5321):564–564. doi: 10.1038/233564a0. [DOI] [PubMed] [Google Scholar]
  9. Kostial K., Simonović I., Pisonić M. Reduction of lead absorption from the intestine in newborn rats. Environ Res. 1971 Oct;4(4):360–363. doi: 10.1016/0013-9351(71)90035-1. [DOI] [PubMed] [Google Scholar]
  10. MACDONALD N. S., SPAIN P. C., EZMIRLIAN F., ROUNDS D. E. The effects of calcium and phosphate in foods on radiostrontium accumulation. J Nutr. 1955 Dec 10;57(4):555–563. doi: 10.1093/jn/57.4.555. [DOI] [PubMed] [Google Scholar]
  11. MORRIS E. R., O'DELL B. L. RELATIONSHIP OF EXCESS CALCIUM AND PHOSPHORUS TO MAGNESIUM REQUIREMENT AND TOXICITY IN GUINEA PIGS. J Nutr. 1963 Oct;81:175–181. doi: 10.1093/jn/81.2.175. [DOI] [PubMed] [Google Scholar]
  12. MacDONALD N. S., NUSBAUM R. E., EZMIRLIAN F., BARBERA R. C., ALEXANDER G. V., SPAIN P., ROUNDS D. E. Gastrointestinal absorption of ions. I. Agents diminishing absorption of strontium. J Pharmacol Exp Ther. 1952 Mar;104(3):348–353. [PubMed] [Google Scholar]
  13. Pentschew A., Garro F. Lead encephalo-myelopathy of the suckling rat and its implications on the porphyrinopathic nervous diseases. With special reference to the permeability disorders of the nervous system's capillaries. Acta Neuropathol. 1966 Jun 1;6(3):266–278. doi: 10.1007/BF00687857. [DOI] [PubMed] [Google Scholar]
  14. Six K. M., Goyer R. A. Experimental enhancement of lead toxicity by low dietary calcium. J Lab Clin Med. 1970 Dec;76(6):933–942. [PubMed] [Google Scholar]
  15. Six K. M., Goyer R. A. The influence of iron deficiency on tissue content and toxicity of ingested lead in the rat. J Lab Clin Med. 1972 Jan;79(1):128–136. [PubMed] [Google Scholar]
  16. Tompsett S. L. The influence of certain constituents of the diet upon the absorption of lead from the alimentary tract. Biochem J. 1939 Aug;33(8):1237–1240. doi: 10.1042/bj0331237. [DOI] [PMC free article] [PubMed] [Google Scholar]

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