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. 1975 Sep;51(599):667–669. doi: 10.1136/pgmj.51.599.667

Pancreatitis, multiple infarcts and oral contraception

M E Foster, D E B Powell
PMCID: PMC2496215  PMID: 1197171

Abstract

The fact that oral contraceptives may predispose to thrombosis is not disputed, although its frequency is still debated. Any reliable assessment of the prevalence of this complication must in the main depend on careful statistical studies of well controlled groups, because the isolated case may well be coincidental when conditions such as coronary thrombosis, cerebral thrombosis, and pulmonary embolism are not extreme rarities in adult women. However, occasionally the clinical and pathological findings are so striking that they afford compelling evidence. The patient to be described presented with clinical features of pancreatitis that did not initially suggest an association with oral contraception. A hitherto undescribed state of multiple infarcts was found at post-mortem. This also illustrates the way in which the official figures for thrombotic complications can be underestimated.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BRAKMAN P., ASTRUP T. EFFECTS OF FEMALE HORMONES, USED AS ORAL CONTRACEPTIVES, ON THE FIBRINOLYTIC SYSTEM IN BLOOD. Lancet. 1964 Jul 4;2(7349):10–12. doi: 10.1016/s0140-6736(64)90005-4. [DOI] [PubMed] [Google Scholar]
  2. Bonnar J., Davidson J. F., Pidgeon C. F., McNicol G. P., Douglas A. S. Fibrin degradation products in normal and abnormal pregnancy and parturition. Br Med J. 1969 Jul 19;3(5663):137–140. doi: 10.1136/bmj.3.5663.137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Howie P. W., Mallinson A. C., Prentice C. R., Horne C. H., McNicol G. P. Effect of combined oestrogen-progestogen oral contraceptives, oestrogen, and progestogen on antiplasmin and antithrombin activity. Lancet. 1970 Dec 26;2(7687):1329–1332. doi: 10.1016/s0140-6736(70)92358-5. [DOI] [PubMed] [Google Scholar]
  4. Pitney W. R. Disseminated intravascular coagulation. Semin Hematol. 1971 Jan;8(1):65–83. [PubMed] [Google Scholar]
  5. Woodfield D. G., Cole S. K., Allan A. G., Cash J. D. Serum fibrin degradation products throughout normal pregnancy. Br Med J. 1968 Dec 14;4(5632):665–668. doi: 10.1136/bmj.4.5632.665. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Ygge J., Brody S., Korsan-Bengtsen K., Nilsson L. Changes in blood coagulation and fibrinolysis in women receiving oral contraceptives. Comparison between treated and untreated women in a longitudinal study. Am J Obstet Gynecol. 1969 May 1;104(1):87–98. doi: 10.1016/s0002-9378(16)34145-x. [DOI] [PubMed] [Google Scholar]

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