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. 1975 Aug;51(598):506–508. doi: 10.1136/pgmj.51.598.506

The role of renin in renal failure associated with hepatic failure

I K Smith
PMCID: PMC2496270  PMID: 1234331

Abstract

A review of the literature has shown that the role of renin in renal failure is not resolved. It has been invoked as an aggravating factor: decreased renal perfusion releasing large quantities of renin sufficient to cause further renal vasoconstriction. If so, then angiotensin generation and action must occur entirely intrarenally since the vasoconstriction appears to be confined entirely to this vascular bed. It may prove necessary to evaluate the renin-angiotensin system within the kidney rather than peripherally. Elevated renin levels in peripheral plasma are at least as likely to be a consequence of reduced renal perfusion as a cause of it.

The few studies so far undertaken of the renin-angiotensin system in renal failure associated with liver disease are inconclusive. If further studies should ascribe a role to renin in the pathology of renal failure, then it may be possible to treat the condition by pharmacological manipulation of the renin-angiotensin system and thereby prevent some of the more serious consequences of renal failure.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barnardo D. E., Summerskill W. H., Strong C. G., Baldus W. P. Renal function, renin activity and endogenous vasoactive substances in cirrhosis. Am J Dig Dis. 1970 May;15(5):419–425. doi: 10.1007/BF02283868. [DOI] [PubMed] [Google Scholar]
  2. Berkowitz H. D., Galvin C. C., Miller L. D. The control of renal cortical perfusion by the renin angiotensin system. Ann Surg. 1974 Feb;179(2):238–245. doi: 10.1097/00000658-197402000-00023. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Berkowitz H. D., Miller L. D., Rosato E. F. Letter: Renin substrate depletion in hepatorenal syndrome. N Engl J Med. 1974 Feb 21;290(8):461–461. doi: 10.1056/nejm197402212900816. [DOI] [PubMed] [Google Scholar]
  4. Brown J. J., Gleadle R. I., Lawson D. H., Lever A. F., Linton A. L., Macadam R. F., Prentice E., Tree M., Robertson J. I. Renin and acute renal failure: studies in man. Br Med J. 1970 Jan 31;1(5691):253–258. doi: 10.1136/bmj.1.5691.253. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Brown W. C., Brown J. J., Gavras H., Jackson A., Lever A. F., McGregor J., MacAdam R. F., Robertson J. I. Renin and acute circulatory renal failure in the rabbit. Circ Res. 1972 Jan;30(1):114–122. doi: 10.1161/01.res.30.1.114. [DOI] [PubMed] [Google Scholar]
  6. DiBona G. F., Sawin L. L. The renin-angiotensin system in acute renal failure in the rat. Lab Invest. 1971 Dec;25(6):528–532. [PubMed] [Google Scholar]
  7. Hofbauer K. G., Zschiedrich H., Rauh W., Gross F. Conversion of angiotensin I into angiotensin II in the isolated perfused rat kidney. Clin Sci. 1973 May;44(5):447–456. doi: 10.1042/cs0440447. [DOI] [PubMed] [Google Scholar]
  8. Iwatsuki S., Popovtzer M. M., Corman J. L., Ishikawa M., Putnam C. W., Katz F. H., Starzl T. E. Recovery from "hepatorenal syndrome" after orthotopic liver transplantation. N Engl J Med. 1973 Nov 29;289(22):1155–1159. doi: 10.1056/NEJM197311292892201. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kokot F., Kuska J. Plasma renin activity in acute renal insufficiency. Nephron. 1969;6(2):115–127. doi: 10.1159/000179720. [DOI] [PubMed] [Google Scholar]
  10. Lauson H. D., Bradley S. E., Cournand A., Andrews V. V. THE RENAL CIRCULATION IN SHOCK. J Clin Invest. 1944 May;23(3):381–402. doi: 10.1172/JCI101506. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Leckie B., Gavras H., McGregor J., McElwee G. The conversion of angiotensin I to angiotensin II by rabbit glomeruli. J Endocrinol. 1972 Oct;55(1):229–230. doi: 10.1677/joe.0.0550229. [DOI] [PubMed] [Google Scholar]
  12. Matthews P. G., Morgan T. O., Johnston C. I. The renin-angiotensin system in acute renal failure in rats. Clin Sci Mol Med. 1974 Jul;47(1):79–88. doi: 10.1042/cs0470079. [DOI] [PubMed] [Google Scholar]
  13. Merrill J. E., Peach M. J., Gilmore J. P. Angiotensin I conversion in the kidney and its modulation by sodium balance. Am J Physiol. 1973 May;224(5):1104–1108. doi: 10.1152/ajplegacy.1973.224.5.1104. [DOI] [PubMed] [Google Scholar]
  14. OLIVER J., MacDOWELL M., TRACY A. The pathogenesis of acute renal failure associated with traumatic and toxic injury; renal ischemia, nephrotoxic damage and the ischemic episode. J Clin Invest. 1951 Dec;30(121):1307–1439. doi: 10.1172/JCI102550. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Powell-Jackson J. D., Brown J. J., Lever A. F., MacGregor J., Macadam R. F., Titterington D. M., Robertson J. I., Waite M. A. Protection against acute renal failure in rats by passive immunisation against angiotensin II. Lancet. 1972 Apr 8;1(7754):774–776. doi: 10.1016/s0140-6736(72)90524-7. [DOI] [PubMed] [Google Scholar]
  16. Schroeder E. T., Eich R. H., Smulyan H., Gould A. B., Gabuzda G. J. Plasma renin level in hepatic cirrhosis. Relaton to functional renal failure. Am J Med. 1970 Aug;49(2):186–191. doi: 10.1016/s0002-9343(70)80074-2. [DOI] [PubMed] [Google Scholar]
  17. Thiel G., McDonald F. D., Oken D. E. Micropuncture studies of the basis for protection of renin depleted rats from glycerol induced acute renal failure. Nephron. 1970;7(1):67–79. doi: 10.1159/000179809. [DOI] [PubMed] [Google Scholar]

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