Abstract
The only final test of the potency of a vaccine is its ability to protect against exposure in an epidemic. Laboratory tests for control purposes attempt to predict this capacity. It is suggested that challenging small groups of volunteers with attenuated influenza virus is a good index of immunity which could be used to check and refine present tests and to evaluate new ones.
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Selected References
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- Beare A. S., Hobson D., Reed S. E., Tyrrell D. A. A comparison of live and killed influenza-virus vaccines. Report to the Medical Research Council's Committee on Influenza and other Respiratory Virus Vaccines. Lancet. 1968 Aug 24;2(7565):418–422. doi: 10.1016/s0140-6736(68)90463-7. [DOI] [PubMed] [Google Scholar]
- Freestone D. S., Hamilton-Smith S., Schild G. C., Buckland R., Chinn S., Tyrrell D. A. Antibody responses and resistance to challenge in volunteers vaccinated with live attenuated, detergent split and oil adjuvant A2-Hong Kong-68 (H 3 N 2 ) influenza vaccines. A report to the Medical Research Council Committee on Influenza and other Respiratory Virus Vaccines. J Hyg (Lond) 1972 Sep;70(3):531–543. doi: 10.1017/s0022172400063117. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Potter C. W., Jennings R., Marine W. M., McLaren C. Potentiation of the antibody response to inactivated A2-Hong Kong vaccines by previous heterotypic influenza virus infection. Microbios. 1973 Sep-Oct;8(30):101–110. [PubMed] [Google Scholar]
- Potter C. W., Jennings R., McLaren C., Clarke A. Immunity following intranasal administration of an inactivated, freeze-dried A/England/42/72 vaccine. Arch Virol. 1975;48(4):307–316. doi: 10.1007/BF01317429. [DOI] [PMC free article] [PubMed] [Google Scholar]