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. 1976 Oct;52(612):631–633. doi: 10.1136/pgmj.52.612.631

Anti-inflammatory action of corticosteroids.

M W Greaves
PMCID: PMC2496363  PMID: 995788

Abstract

The anti-inflammatory action of corticosteroids is complex. At a cellular level, they cause redistribution of granulocytes, resulting in increased circulating granulocytes and reduced tissue pools. They also cause lymphopenia. The significance of these phenomena in relation to the anti-inflammatory activity of steroids is unknown. The most obvious pharmacological effects of corticosteroids are seen on blood vessels. They cause adrenergically mediated vasoconstriction and non-competitive antagonism of vasodilation due to prostaglanin E and bradykinin. Prostaglandin formation is inhibited by corticosteroids but whether this is due to an effect on enzymic synthesis or release is uncertain. Corticosteroids stabilize the lysosomal membrane preventing release of lysosomal enzymes in vitro but the significance of this in vivo is debatable.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BUSH I. E. Chemical and biological factors in the activity of adrenocortical steroids. Pharmacol Rev. 1962 Sep;14:317–445. [PubMed] [Google Scholar]
  2. Claman H. N. How corticosteroids work. J Allergy Clin Immunol. 1975 Mar;55(3):145–151. doi: 10.1016/0091-6749(75)90010-x. [DOI] [PubMed] [Google Scholar]
  3. Crunkhorn P., Willis A. L. Interaction between prostaglandins E and F given intradermally in the rat. Br J Pharmacol. 1971 Mar;41(3):507–512. doi: 10.1111/j.1476-5381.1971.tb08048.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Greaves M. W., McDonald-Gibson W. Prostaglandin biosynthesis by human skin and its inhibition by corticosteroids. Br J Pharmacol. 1972 Sep;46(1):172–175. doi: 10.1111/j.1476-5381.1972.tb06861.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Kantrowitz F., Robinson D. R., McGuire M. B., Levine L. Corticosteroids inhibit prostaglandin production by rheumatiod synovia. Nature. 1975 Dec 25;258(5537):737–739. doi: 10.1038/258737a0. [DOI] [PubMed] [Google Scholar]
  6. Lewis G. P., Piper P. J. Inhibition of release of prostaglandins as an explanation of some of the actions of anti-inflammatory corticosteroids. Nature. 1975 Mar 27;254(5498):308–311. doi: 10.1038/254308a0. [DOI] [PubMed] [Google Scholar]
  7. Lichtenstein L. M., Gillespie E., Bourne H. R., Henney C. S. The effects of a series of prostaglandins on in vitro models of the allergic response and cellular immunity. Prostaglandins. 1972 Dec;2(6):519–528. doi: 10.1016/s0090-6980(72)80040-6. [DOI] [PubMed] [Google Scholar]
  8. Moncada S., Ferreira S. H., Vane J. R. Prostaglandins, aspirin-like drugs and the oedema of inflammation. Nature. 1973 Nov 23;246(5430):217–219. doi: 10.1038/246217a0. [DOI] [PubMed] [Google Scholar]
  9. Peters W. P., Holland J. F., Senn H., Rhomberg W., Banerjee T. Corticosteroid administration and localized leukocyte mobilization in man. N Engl J Med. 1972 Feb 17;286(7):342–345. doi: 10.1056/NEJM197202172860703. [DOI] [PubMed] [Google Scholar]
  10. SOLOMON L. M., WENTZEL H. E., GREENBERG M. S. STUDIES IN THE MECHANISM OF STEROID VASOCONSTRICTION. J Invest Dermatol. 1965 Feb;44:129–131. doi: 10.1038/jid.1965.23. [DOI] [PubMed] [Google Scholar]
  11. Vane J. R. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol. 1971 Jun 23;231(25):232–235. doi: 10.1038/newbio231232a0. [DOI] [PubMed] [Google Scholar]
  12. Ward P. A. The chemosuppression of chemotaxis. J Exp Med. 1966 Aug 1;124(2):209–226. doi: 10.1084/jem.124.2.209. [DOI] [PMC free article] [PubMed] [Google Scholar]

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