Skip to main content
Postgraduate Medical Journal logoLink to Postgraduate Medical Journal
. 1977 Mar;53(617):173–174. doi: 10.1136/pgmj.53.617.173

Acute leukaemia during azathioprine therapy.

I T Gilmore, G Holden, K S Rodan
PMCID: PMC2496469  PMID: 266170

Abstract

Various tumours, in particular lymphomas, have been reported in association with azathioprine treatment, both after renal transplantation and in other conditions. A case is reported here of acute myeloid leukaemia associated with azathioprine therapy for rheumatoid arthritis, and this is now the third case reported in the world literature of leukaemia arising during azathioprine therapy for a non-malignant condition.

Full text

PDF
173

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Casey T. P. Azathioprine (Imuran) administration and the development of malignant lymphomas in NZB mice. Clin Exp Immunol. 1968 May;3(4):305–312. [PMC free article] [PubMed] [Google Scholar]
  2. Doll R., Kinlen L. Immunosurveillance and cancer: epidemiological evidence. Br Med J. 1970 Nov 14;4(5732):420–422. doi: 10.1136/bmj.4.5732.420. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Keast D. Immunosurveillance and cancer. Lancet. 1970 Oct 3;2(7675):710–712. doi: 10.1016/s0140-6736(70)91973-2. [DOI] [PubMed] [Google Scholar]
  4. LEA A. J. AN ASSOCIATION BETWEEN THE RHEUMATIC DISEASES AND THE RETICULOSES. Ann Rheum Dis. 1964 Nov;23:480–484. doi: 10.1136/ard.23.6.480. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Maldonado N., Torres V. M., Méndez-Cashion D., Pérez-Santiago E., Cáceres de Costas M. Pyoderma gangrenosum treated with 6-mercaptopurine and followed by acute leukemia. J Pediatr. 1968 Mar;72(3):409–414. doi: 10.1016/s0022-3476(68)80218-5. [DOI] [PubMed] [Google Scholar]
  6. McAdam L., Paulus H. E., Peter J. B. Adenocarcinoma of the lung during azathioprine therapy. Arthritis Rheum. 1974 Jan-Feb;17(1):92–94. doi: 10.1002/art.1780170114. [DOI] [PubMed] [Google Scholar]
  7. Miller D. G. The association of immune disease and malignant lymphoma. Ann Intern Med. 1967 Mar;66(3):507–521. doi: 10.7326/0003-4819-66-3-507. [DOI] [PubMed] [Google Scholar]
  8. Sharpstone P., Ogg C. S., Cameron J. S. Nephrotic syndrome due to primary renal disease in adults: II. A controlled trial of prednisolone and azathioprine. Br Med J. 1969 May 31;2(5656):535–539. doi: 10.1136/bmj.2.5656.535. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Silvergleid A. J., Schrier S. L. Acute myelogenous leukemia in two patients treated with azathioprine for nonmalignant diseases. Am J Med. 1974 Dec;57(6):885–888. doi: 10.1016/0002-9343(74)90165-x. [DOI] [PubMed] [Google Scholar]
  10. Woodruff M. Immunosuppression and its complications. Proc R Soc Med. 1969 Apr;62(4):411–416. doi: 10.1177/003591576906200454. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Worlledge S. M., Brain M. C., Cooper A. C., Hobbs J. R., Dacie J. V. Immmunosuppressive drugs in the treatment of autoimmune haemolytic anaemia. Proc R Soc Med. 1968 Dec 12;61(12):1312–1315. doi: 10.1177/003591576806101237. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Postgraduate Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES