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. 1977 Mar;53(617):126–129. doi: 10.1136/pgmj.53.617.126

The different effects of sodium bicarbonate and aluminium hydroxide on the absorption of indomethacin in man.

J C Garnham, T Kaspi, C M Kaye, V M Oh
PMCID: PMC2496481  PMID: 16256

Abstract

The influence of oral sodium bicarbonate and aluminium hydroxide on the absorption of indomethacin has been studied in normal volunteers. While sodium bicarbonate appeared to increase indomethacin absorption, aluminium hydroxide markedly reduced both the rate and extent of absorption. The buccal absorption of indomethacin over the pH range 5-9 was also studied in normal volunteers, and showed that the percentage absorption increased markedly as the pH was reduced. The clinical importance both of pH-partition and of adsorption are discussed in the context of antacid interactions. It is concluded that caution must be exercised when prescribing an antacid with other orally-administered drugs.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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