Abstract
A case of severe diarrhoea and steatorrhoea following chemotherapy and abdominal irradiation for lymphosarcoma, is described. Investigations demonstrated bile acid malabsorption, and treatment with cholesytramine and a low fat diet was successful. A questionnaire was sent to thirty-two subjects who had undergone similar treatment for similar pathology and failed to demonstrate any sustained alteration of bowel function. Additionally, nine of these subjects underwent a 14C-glycocholic acid test and no evidence of interruption of the enterohepatic circulation of bile acids was found.
Full text
PDF


Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Duncan W., Leonard J. C. The malabsorption syndrome following radiotherapy. Q J Med. 1965 Jul;34(135):319–329. [PubMed] [Google Scholar]
- Fromm D. Ileal resection, or disease, and the blind loop syndrome: current concepts of pathophysiology. Surgery. 1973 May;73(5):639–648. [PubMed] [Google Scholar]
- Fromm H., Hofmann A. F. Breath test for altered bile-acid metabolism. Lancet. 1971 Sep 18;2(7725):621–625. doi: 10.1016/s0140-6736(71)80068-5. [DOI] [PubMed] [Google Scholar]
- HALLS J. M. RADIATION DAMAGE OF THE SMALL INTESTINE. Clin Radiol. 1965 Apr;16:173–176. doi: 10.1016/s0009-9260(65)80019-8. [DOI] [PubMed] [Google Scholar]
- Newman A., Katsaris J., Blendis L. M., Charlesworth M., Walter L. H. Small-intestinal injury in women who have had pelvic radiotherapy. Lancet. 1973 Dec 29;2(7844):1471–1473. doi: 10.1016/s0140-6736(73)92732-3. [DOI] [PubMed] [Google Scholar]
- Sheltawy M. J., Losowsky M. S. Determination of faecal bile acids by an enzymic method. Clin Chim Acta. 1975 Oct 15;64(2):127–132. doi: 10.1016/0009-8981(75)90194-1. [DOI] [PubMed] [Google Scholar]
- Sobo A. O., Johnston I. D. The effect of therapeutic irradiation of the abdomen on intestinal absorption in man. Am J Gastroenterol. 1973 Dec;60(6):616–624. [PubMed] [Google Scholar]
- Tankel H. I., Clark D. H., Lee F. D. Radiation enteritis with malabsorption. Gut. 1965 Dec;6(6):560–569. doi: 10.1136/gut.6.6.560. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wiernik G. Changes in the villous pattern of the human jejunum associated with heavy radiation damage. Gut. 1966 Apr;7(2):149–153. doi: 10.1136/gut.7.2.149. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wiggins H. S. Simple method for estimating trypsin. Gut. 1967 Aug;8(4):415–416. doi: 10.1136/gut.8.4.415. [DOI] [PMC free article] [PubMed] [Google Scholar]
