Skip to main content
NCBI home page
Postgraduate Medical Journal logoLink to Postgraduate Medical Journal
. 1977 Apr;53(618):212–215. doi: 10.1136/pgmj.53.618.212

Barbiturates and serum calcium in the elderly.

R E Young, L E Ramsay, T S Murray
PMCID: PMC2496495  PMID: 323838

Abstract

In a retrospective study, based on a biochemical survey of people aged 65 and over in a general practice, subjects taking a barbiturate preparation for indications other than epilepsy had a significantly lower serum calcium concentration than did those taking nitrazepam or diazepam. Ordinary doses of barbiturate may adversely affect vitamin D metabolism in the elderly.

Full text

PDF
212

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Christiansen C., Rodbro P., Munck O. Actions of vitamins D2 and D3 and 25-OHD3 in anticonvulsant osteomalacia. Br Med J. 1975 May 17;2(5967):363–365. doi: 10.1136/bmj.2.5967.363. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Dent C. E., Richens A., Rowe D. J., Stamp T. C. Osteomalacia with long-term anticonvulsant therapy in epilepsy. Br Med J. 1970 Oct 10;4(5727):69–72. doi: 10.1136/bmj.4.5727.69. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Fraser H. S., Thompson D., Khan C. Clinical application of antipyrine half life in saliva in a patient with osteomalacia. Br Med J. 1976 Jun 19;1(6024):1507–1508. doi: 10.1136/bmj.1.6024.1507. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Greenwood R. H., Prunty F. T., Silver J. Osteomalacia after prolonged glutethimide administration. Br Med J. 1973 Mar 17;1(5854):643–645. doi: 10.1136/bmj.1.5854.643. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hahn T. J., Hendin B. A., Scharp C. R., Haddad J. G., Jr Effect of chronic anticonvulsant therapy on serum 25-hydroxycalciferol levels in adults. N Engl J Med. 1972 Nov 2;287(18):900–904. doi: 10.1056/NEJM197211022871803. [DOI] [PubMed] [Google Scholar]
  6. Hunter J. Enzyme induction and medical treatment. J R Coll Physicians Lond. 1974 Jan;8(2):163–174. [PMC free article] [PubMed] [Google Scholar]
  7. Kruse R. Osteopathien bei antiepileptischer Langzeittherapie (Vorläufige Mitteilung) Monatsschr Kinderheilkd. 1968 Jun;116(6):378–381. [PubMed] [Google Scholar]
  8. Payne R. B., Little A. J., Williams R. B., Milner J. R. Interpretation of serum calcium in patients with abnormal serum proteins. Br Med J. 1973 Dec 15;4(5893):643–646. doi: 10.1136/bmj.4.5893.643. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Pierides A. M., Ellis H. A., Ward M., Simpson W., Peart K. M., Alvarez-ude F., Uldall P. R., Kerr D. N. Barbiturate and anticonvulsant treatment in relation to osteomalacia with haemodialysis and renal transplantation. Br Med J. 1976 Jan 24;1(6003):190–193. doi: 10.1136/bmj.1.6003.190. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Richens A., Rowe D. J. Disturbance of calcium metabolism by anticonvulsant drugs. Br Med J. 1970 Oct 10;4(5727):73–76. doi: 10.1136/bmj.4.5727.73. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Whitfield J. B., Moss D. W., Neale G., Orme M., Breckenridge A. Changes in plasma -glutamyl transpeptidase activity associated with alterations in drug metabolism in man. Br Med J. 1973 Feb 10;1(5849):316–318. doi: 10.1136/bmj.1.5849.316. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Postgraduate Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES