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. 1976 May;52(607):251–253. doi: 10.1136/pgmj.52.607.251

Chlorpropamide and fibrinolytic activity in maturity onset diabetes mellitus

William D Alexander, R T Wensley, Geraldine Price, M Hartog
PMCID: PMC2496508  PMID: 959097

Abstract

This study was performed to assess the effect of chlorpropamide therapy on the fibrinolytic activity of blood of maturity onset diabetics. Normal controls were also studied and the results compared with diabetics. Diabetics were found to have deficient fibrinolytic activity compared with non-diabetics but chlorpropamide did not appear significantly to affect this deficiency either in males or females when given therapeutically over a 6-month period.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. DENBOROUGH M. A., PATERSON B. Clearing factor, fibrinolysis and blood lipids in diabetes mellitus. Clin Sci. 1962 Dec;23:485–488. [PubMed] [Google Scholar]
  2. EASTHAM R. D. An improved plasma recalcified clotting test and its modification as a simple rapid heparin retarded clotting test. J Clin Pathol. 1962 Jan;15:86–87. doi: 10.1136/jcp.15.1.86. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. FEARNLEY G. R., CHAKRABARTI R., AVIS P. R. Blood fibrinolytic activity in diabetes mellitus and its bearing on ischaemic heart disease and obesity. Br Med J. 1963 Apr 6;1(5335):921–923. doi: 10.1136/bmj.1.5335.921. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. FEARNLEY G. R., CHAKRABARTI R. PHARMACOLOGICAL ENCHANCEMENT OF FIBRINOLYTIC ACTIVITY OF BLOOD. J Clin Pathol. 1964 May;17:328–332. doi: 10.1136/jcp.17.3.328. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. FEARNLEY G. R., CHAKRABARTI R., VINCENT C. T. Effect of the sulphonylureas on fibrinolysis. Lancet. 1960 Sep 17;2(7151):622–625. doi: 10.1016/s0140-6736(60)91694-9. [DOI] [PubMed] [Google Scholar]
  6. FEARNLEY G. R., TWEED J. M. Evidence of an active fibrinolytic enzyme in the plasma of normal people with observations on inhibition associated with the presence of calcium. Clin Sci. 1953 Feb;12(1):81–89. [PubMed] [Google Scholar]
  7. FEARNLEY G. R., VINCENT C. T., CHAKRABARTI R. Reduction of blood fibrinolytic activity in diabetes mellitus by insulin. Lancet. 1959 Dec 12;2(7111):1067–1067. doi: 10.1016/s0140-6736(59)91534-x. [DOI] [PubMed] [Google Scholar]
  8. Farid N. R., Anderson J., Martin A., Weightman D. Letter: Fibrinolytic activity and treatment of diabetes. Lancet. 1974 Apr 6;1(7858):631–632. doi: 10.1016/s0140-6736(74)92695-6. [DOI] [PubMed] [Google Scholar]
  9. Fearnley G. R., Chakrabarti R. Fibrinolytic treatment of rheumatoid arthritis with phenformin plus ethyloestrenol. Lancet. 1966 Oct 8;2(7467):757–761. doi: 10.1016/s0140-6736(66)90360-6. [DOI] [PubMed] [Google Scholar]
  10. HATHORN M., GILLMAN T., CAMPBELL G. D. Blood lipids, mucoproteins, and fibrinolytic activity in diabetic Indians and Africans in Natal. Possible relation to vascular complications. Lancet. 1961 Jun 17;1(7190):1314–1318. doi: 10.1016/s0140-6736(61)90239-2. [DOI] [PubMed] [Google Scholar]
  11. MACKAY N., HUME R. FIBRINOLYTIC ACTIVITY IN DIABETES MELLITUS. Scott Med J. 1964 Sep;9:359–364. doi: 10.1177/003693306400900901. [DOI] [PubMed] [Google Scholar]
  12. Moore G. R., Barnes I. C., Pennock C. A. An improved rapid automated method for the estimation of blood glucose. Clin Chim Acta. 1972 Oct;41:439–440. doi: 10.1016/0009-8981(72)90538-4. [DOI] [PubMed] [Google Scholar]
  13. TSAPOGAS M. J., COTTON L. T., FLUTE P. T., MURRAY J. G. The effects of chlorpropamide on intermittent claudication and fibrinolysis. Lancet. 1962 Jun 9;1(7241):1213–1215. doi: 10.1016/s0140-6736(62)92255-9. [DOI] [PubMed] [Google Scholar]

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