Abstract
Where practicable, all subjects found with onset-phase-four blood pressure of 90 mmHg or more after referral were allocated, on a random basis, to alternative antihypertensive regimes at a dosage related to response. Of those 110 receiving either guanethidine, methyldopa or debrisoquine, only the group on methyldopa had significantly reduced median blood pressure by two out of four criteria and after 6 months of therapy. It is nevertheless considered that by assessment of the total group more significant conclusions can be drawn for an eventual attempt to control hypertension on a community basis than by studies of highly selected groups treated under unusually favourable conditions.
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Selected References
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- Dollery C. T. Adrenergic drugs in the treatment of hypertension. Br Med Bull. 1973 May;29(2):158–162. doi: 10.1093/oxfordjournals.bmb.a070987. [DOI] [PubMed] [Google Scholar]
- Fry J. Natural history of hypertension. A case for selective non-treatment. Lancet. 1974 Aug 24;2(7878):431–433. doi: 10.1016/s0140-6736(74)91816-9. [DOI] [PubMed] [Google Scholar]
- Guyton A. C., Coleman T. G., Cowley A. V., Jr, Scheel K. W., Manning R. D., Jr, Norman R. A., Jr Arterial pressure regulation. Overriding dominance of the kidneys in long-term regulation and in hypertension. Am J Med. 1972 May;52(5):584–594. doi: 10.1016/0002-9343(72)90050-2. [DOI] [PubMed] [Google Scholar]
- Idiopathic cardiomegaly. Bull World Health Organ. 1968;38(6):979–992. [PMC free article] [PubMed] [Google Scholar]
- Kannel W. B., Gordon T., Schwartz M. J. Systolic versus diastolic blood pressure and risk of coronary heart disease. The Framingham study. Am J Cardiol. 1971 Apr;27(4):335–346. doi: 10.1016/0002-9149(71)90428-0. [DOI] [PubMed] [Google Scholar]
- Proger S. Antihypertensive drugs: praise and restraint. N Engl J Med. 1972 Jan 20;286(3):155–156. doi: 10.1056/NEJM197201202860310. [DOI] [PubMed] [Google Scholar]
- Stuart K. L., MacIver C., Nicholson J. A. Outpatient treatment trial of mild and severe hypertension. Br Med J. 1972 Apr 1;2(5804):21–24. doi: 10.1136/bmj.2.5804.21. [DOI] [PMC free article] [PubMed] [Google Scholar]