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. 1977 Jun;53(620):321–324. doi: 10.1136/pgmj.53.620.321

A case of myasthenia gravis treated with steroids: some suggestions for the mechanisms underlying their effect.

P Dandona, E J Corkan, G E Sladen
PMCID: PMC2496642  PMID: 887530

Abstract

This report deals with a patient with long standing myasthenia gravis treated with a small dose of corticosteroids. The response to treatment was prompt and the post-therapeutic deterioration in function was minimal and cholinergic in nature. It is suggested that the dose of anticholinesterases be reduced concomitantly with the institution of steroid treatment.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bender A. N., Ringel S. P., Engel W. K., Daniels M. P., Vogel Z. Myasthenia gravis: a serum factor blocking acetylcholine receptors of the human neuromuscular junction. Lancet. 1975 Mar 15;1(7907):607–609. doi: 10.1016/s0140-6736(75)91886-3. [DOI] [PubMed] [Google Scholar]
  2. Brunner N. G., Namba T., Grob D. Corticosteroids in management of severe, generalized myasthenia gravis. Effectiveness and comparison with corticotropin therapy. Neurology. 1972 Jun;22(6):603–610. doi: 10.1212/wnl.22.6.603. [DOI] [PubMed] [Google Scholar]
  3. Cape C. A., Utterback R. A. Maintenance adrenocorticotropic hormone (ACTH) treatment in myasthenia gravis. Neurology. 1972 Nov;22(11):1160–1164. doi: 10.1212/wnl.22.11.1160. [DOI] [PubMed] [Google Scholar]
  4. ELMQVIST D., HOFMANN W. W., KUGELBERG J., QUASTEL D. M. AN ELECTROPHYSIOLOGICAL INVESTIGATION OF NEUROMUSCULAR TRANSMISSION IN MYASTHENIA GRAVIS. J Physiol. 1964 Nov;174:417–434. doi: 10.1113/jphysiol.1964.sp007495. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Genkins G., Kornfeld P., Osserman K. E., Namba T., Grob D., Brunner N. G. The use of ACTH and corticosteroids in myasthenia gravis. Ann N Y Acad Sci. 1971 Sep 15;183:369–374. doi: 10.1111/j.1749-6632.1971.tb30766.x. [DOI] [PubMed] [Google Scholar]
  6. Liversedge L. A., Yuill G. M., Wilkinson I. M., Hughes J. A. Benefit from adrenocorticotrophin in myasthenia gravis. J Neurol Neurosurg Psychiatry. 1974 Apr;37(4):412–415. doi: 10.1136/jnnp.37.4.412. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. MILEDI R. The acetylcholine sensitivity of frog muscle fibres after complete or partial devervation. J Physiol. 1960 Apr;151:1–23. [PMC free article] [PubMed] [Google Scholar]
  8. Turner J. W. President's address. Myasthenia gravis. Proc R Soc Med. 1974 Aug;67(8):763–769. doi: 10.1177/003591577406700838. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Wilson R. W., Ward M. D., Johns T. R. Corticosteroids: a direct effect at the neuromuscular junction. Neurology. 1974 Nov;24(11):1091–1095. doi: 10.1212/wnl.24.11.1091. [DOI] [PubMed] [Google Scholar]

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