Abstract
Infusions of fructose or sorbitol are used commonly in parenteral nutrition and may cause lactic acidosis. A case is reported in whom blood lactate concentration was monitored frequently over a 5-day period during intravenous feeding with a sorbitol-ethanol-amino acid mixture. During the first five infusions blood lactate rose only moderately, but with the final infusion lactate rose to 11-1 mmol/l and the patient had a severe metabolic acidosis. In retrospect the patient had shown deterioration in renal and hepatic function tests during the preceding 24 hr. On terminating the infusions the blood lactate concentration fell rapidly. It is suggested that great care should be exercised when using such infusions in ill patients and acid base status and renal and hepatic function should be monitored frequently.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Cohen R. D., Simpson R. Lactate metabolism. Anesthesiology. 1975 Dec;43(6):661–673. doi: 10.1097/00000542-197512000-00013. [DOI] [PubMed] [Google Scholar]
- Lloyd M. H., Iles R. A., Simpson B. R., Strunin J. M., Layton J. M., Cohen R. D. The effect of simulated metabolic acidosis on intracellular pH and lactate metabolism in the isolated perfused rat liver. Clin Sci Mol Med. 1973 Oct;45(4):543–549. doi: 10.1042/cs0450543. [DOI] [PubMed] [Google Scholar]
- Woods H. F., Alberti K. G. Dangers of intravenous fructose. Lancet. 1972 Dec 23;2(7791):1354–1357. doi: 10.1016/s0140-6736(72)92791-2. [DOI] [PubMed] [Google Scholar]