Abstract
Most serious neonatal streptococcal infections are caused by group-B streptococci. The pattern of serious group-B neonatal disease in Britain resembles that described in other countries; both "early-onset" and "late-onset" forms are seen, but reliable incidence rates have not yet been determined. Serological-type III strains predominate in neonatal meningitis in Britain, but not so markedly as in some parts of the U.S.A. A deficiency of group-II strains in meningitis is, however, apparent in both countries. Present information about the carriage of group-B streptococci suggests that antibiotic prophylaxis administered to mothers or infants is unlikely to reduce greatly the frequency of "early-onset" disease. The continuous presence of a suitable chemical disinfectant in the vagina during labour might be more effective. Insufficient is known about the epidemiology of "late-onset" neonatal disease for rational preventive measures to be designed. More information is required about the postnatal acquisition of group-B streptococci by neonates and its sources, and about passive transfer of type-specific antibody from the mother to her child.
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- Ablow R. C., Driscoll S. G., Effmann E. L., Gross I., Jolles C. J., Uauy R., Warshaw J. B. A comparison of early-onset group B steptococcal neonatal infection and the respiratory-distress syndrome of the newborn. N Engl J Med. 1976 Jan 8;294(2):65–70. doi: 10.1056/NEJM197601082940201. [DOI] [PubMed] [Google Scholar]
- Anthony B. F., Concepcion N. F. Group B streptococcus in a general hospital. J Infect Dis. 1975 Nov;132(5):561–567. doi: 10.1093/infdis/132.5.561. [DOI] [PubMed] [Google Scholar]
- BOISSARD J. M., ETON B. Neonatal umbilicus as a source of streptococcal infections in a maternity unit. Br Med J. 1956 Sep 8;2(4992):574–576. doi: 10.1136/bmj.2.4992.574. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Baker C. J., Barrett F. F. Group B streptococcal infections in infants. The importance of the various serotypes. JAMA. 1974 Nov 25;230(8):1158–1160. [PubMed] [Google Scholar]
- Baker C. J., Barrett F. F. Transmission of group B streptococci among parturient women and their neonates. J Pediatr. 1973 Dec;83(6):919–925. doi: 10.1016/s0022-3476(73)80524-4. [DOI] [PubMed] [Google Scholar]
- Baker C. J., Kasper D. L. Correlation of maternal antibody deficiency with susceptibility to neonatal group B streptococcal infection. N Engl J Med. 1976 Apr 1;294(14):753–756. doi: 10.1056/NEJM197604012941404. [DOI] [PubMed] [Google Scholar]
- Bret A. J., Durieux R. Méningite du nouveau-né et infection vaginale à streptocoque B. Diagnostic différentiel avec le pneumocoque saprophyte et pathogénicité. Rev Fr Gynecol Obstet. 1965 Dec;60(12):785–788. [PubMed] [Google Scholar]
- Brown J. H. Double-Zone Beta-Hemolytic Streptococci: Their Cultural Characteristics, Serological Grouping, Occurrence and Pathogenic Significance. J Bacteriol. 1939 Feb;37(2):133–144. doi: 10.1128/jb.37.2.133-144.1939. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dolphin A., Cruickshank R. Penicillin Therapy in Acute Bacterial Endocarditis. Br Med J. 1945 Jun 30;1(4408):897–901. doi: 10.1136/bmj.1.4408.897. [DOI] [PMC free article] [PubMed] [Google Scholar]
- EICKHOFF T. C., KLEIN J. O., DALY A. K., INGALL D., FINLAND M. NEONATAL SEPSIS AND OTHER INFECTIONS DUE TO GROUP B BETA-HEMOLYTIC STREPTOCOCCI. N Engl J Med. 1964 Dec 10;271:1221–1228. doi: 10.1056/NEJM196412102712401. [DOI] [PubMed] [Google Scholar]
- Etienne M., Curioni S., Laplane R. La gravité des méningites bactériennes néonatales. Ann Pediatr (Paris) 1965 Jun-Jul;12(6):421–433. [PubMed] [Google Scholar]
- Ferrieri P., Cleary P. P., Seeds A. E. Epidemiology of group-B streptococcal carriage in pregnant women and newborn infants. J Med Microbiol. 1977 Feb;10(1):103–114. doi: 10.1099/00222615-10-1-103. [DOI] [PubMed] [Google Scholar]
- Finch R. G., French G. L., Phillips I. Group B streptococci in the female genital tract. Br Med J. 1976 May 22;1(6020):1245–1247. doi: 10.1136/bmj.1.6020.1245. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Franciosi R. A., Knostman J. D., Zimmerman R. A. Group B streptococcal neonatal and infant infections. J Pediatr. 1973 Apr;82(4):707–718. doi: 10.1016/s0022-3476(73)80604-3. [DOI] [PubMed] [Google Scholar]
- GRAY J. D. A. Outbreak of streptococcal infection in a maternity unit. Lancet. 1956 Jul 21;271(6934):132–136. [PubMed] [Google Scholar]
- HOOD M., JANNEY A., DAMERON G. Beta hemolytic streptococcus group B associated with problems of the perinatal period. Am J Obstet Gynecol. 1961 Oct;82:809–818. doi: 10.1016/s0002-9378(16)36146-4. [DOI] [PubMed] [Google Scholar]
- Hall W. H. Purpura fulminans with group B Beta-hemolytic streptococcal endocarditis. Arch Intern Med. 1965 Oct;116(4):594–597. [PubMed] [Google Scholar]
- Harper I. A. The importance of group B streptococci as human pathogens in the British Isles. J Clin Pathol. 1971 Jul;24(5):438–441. doi: 10.1136/jcp.24.5.438. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Howard J. B., McCracken G. H., Jr The spectrum of group B streptococcal infections in infancy. Am J Dis Child. 1974 Dec;128(6):815–818. doi: 10.1001/archpedi.1974.02110310063011. [DOI] [PubMed] [Google Scholar]
- JAMES J. R., KWANTES W. Haemolytic streptococci on the neonatal umbilicus. Br Med J. 1956 Sep 8;2(4992):576–578. doi: 10.1136/bmj.2.4992.576. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jones H. E., Howells C. H. Neonatal meningitis due to Streptococcus agalactiae. Postgrad Med J. 1968 Jul;44(513):549–551. doi: 10.1136/pgmj.44.513.549. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KAHLER J., AICHER J. Der Galtstreptokokkus als Erreger einer ulzero-polypösen Endokarditis beim Menschen. Zentralbl Allg Pathol. 1952 Mar-Apr;88(8-9):312–317. [PubMed] [Google Scholar]
- KEXEL G., SCHOENBOHM S. STREPTOCOCCUS AGALACTIAE ALS ERREGER VON SAEUGLINGSMENINGITIDEN. Dtsch Med Wochenschr. 1965 Feb 5;90:258–261. doi: 10.1055/s-0028-1111328. [DOI] [PubMed] [Google Scholar]
- Katzenstein A. L., Davis C., Braude A. Pulmonary changes in neonatal sepsis to group B beta-hemolytic Streptococcus: relation of hyaline membrane disease. J Infect Dis. 1976 Apr;133(4):430–435. doi: 10.1093/infdis/133.4.430. [DOI] [PubMed] [Google Scholar]
- Kexel G., Beck K. J. Untersuchungen über die Häufigkeit der B-Streptokokken im Wochenbett. Geburtshilfe Frauenheilkd. 1965 Nov;25(11):1078–1085. [PubMed] [Google Scholar]
- Kvittingen J. Beta-haemolytic Streptococcus group B causing neonatal meningitis. Acta Pathol Microbiol Scand. 1968;74(1):143–144. doi: 10.1111/j.1699-0463.1968.tb03465.x. [DOI] [PubMed] [Google Scholar]
- LANGEWISCH W. H. An epidemic of group A. type 1 streptococcal infections in newborn infants. Pediatrics. 1956 Sep;18(3):438–447. [PubMed] [Google Scholar]
- LAZARUS J. M., SELLERS D. P., MARINE W. M. MENINGITIS DUE TO THE GROUP B BETA-HEMOLYTIC STREPTOCOCCUS. N Engl J Med. 1965 Jan 21;272:146–147. doi: 10.1056/NEJM196501212720308. [DOI] [PubMed] [Google Scholar]
- Lafaix C., Duval J., Camerlynck P., Guérin M., Rey M. Méningite néonatale à streptocoque B (à propos de deux cas observés à Dakar) Bull Soc Med Afr Noire Lang Fr. 1968;13(1):181–183. [PubMed] [Google Scholar]
- Lancefield R. C. A SEROLOGICAL DIFFERENTIATION OF SPECIFIC TYPES OF BOVINE HEMOLYTIC STREPTOCOCCI (GROUP B). J Exp Med. 1934 Mar 31;59(4):441–458. doi: 10.1084/jem.59.4.441. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lancefield R. C., Hare R. THE SEROLOGICAL DIFFERENTIATION OF PATHOGENIC AND NON-PATHOGENIC STRAINS OF HEMOLYTIC STREPTOCOCCI FROM PARTURIENT WOMEN. J Exp Med. 1935 Feb 28;61(3):335–349. doi: 10.1084/jem.61.3.335. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lancefield R. C., McCarty M., Everly W. N. Multiple mouse-protective antibodies directed against group B streptococci. Special reference to antibodies effective against protein antigens. J Exp Med. 1975 Jul 1;142(1):165–179. doi: 10.1084/jem.142.1.165. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lancefield R. C. TWO SEROLOGICAL TYPES OF GROUP B HEMOLYTIC STREPTOCOCCI WITH RELATED, BUT NOT IDENTICAL, TYPE-SPECIFIC SUBSTANCES. J Exp Med. 1938 Jan 1;67(1):25–40. doi: 10.1084/jem.67.1.25. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Maher E., Irwin R. C. Group B streptococcal infection in infancy: a case report and review. Pediatrics. 1966 Oct;38(4):659–661. [PubMed] [Google Scholar]
- Mathews J. H., Klesius P. H., Zimmerman R. A. Opsonin system of the group B streptococcus. Infect Immun. 1974 Dec;10(6):1315–1320. doi: 10.1128/iai.10.6.1315-1320.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
- NYHAN W. L., FOUSEK M. D. Septicemia of the newborn. Pediatrics. 1958 Aug;22(2):268–278. [PubMed] [Google Scholar]
- PATTISON I. H., MATTHEWS P. R., MAXTED W. R. Type classification by Lancefield's precipitin method of human and bovine group-B streptococci isolated in Britain. J Pathol Bacteriol. 1955 Jan-Apr;69(1-2):43–50. doi: 10.1002/path.1700690108. [DOI] [PubMed] [Google Scholar]
- Parker M. T., Ball L. C. Streptococci and aerococci associated with systemic infection in man. J Med Microbiol. 1976 Aug;9(3):275–302. doi: 10.1099/00222615-9-3-275. [DOI] [PubMed] [Google Scholar]
- Quirante J., Ceballos R., Cassady G. Group B beta-hemolytic streptococcal infection in the newborn. I. Early onset infection. Am J Dis Child. 1974 Nov;128(5):659–665. doi: 10.1001/archpedi.1974.02110300069009. [DOI] [PubMed] [Google Scholar]
- REINARZ J. A., SANFORD J. P. HUMAN INFECTIONS CAUSED BY NON-GROUP A OR D STREPTOCOCCI. Medicine (Baltimore) 1965 Jan;44:81–96. doi: 10.1097/00005792-196501000-00003. [DOI] [PubMed] [Google Scholar]
- Reid T. M. Emergence of group B streptococci in obstetric and perinatal infections. Br Med J. 1975 Jun 7;2(5970):533–535. doi: 10.1136/bmj.2.5970.533. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sicherman M. J. Septicemia due to group B streptococcus: report of two siblings presenting with lesions resembling erythema nodosum. Pediatrics. 1965 Dec;36(6):937–939. [PubMed] [Google Scholar]
- Steere A. C., Aber R. C., Warford L. R., Murphy K. E., Feeley J. C., Hayes P. S., Wilkinson H. W., Facklam R. R. Possible nosocomial transmission of group B streptococci in a newborn nursery. J Pediatr. 1975 Nov;87(5):784–787. doi: 10.1016/s0022-3476(75)80311-8. [DOI] [PubMed] [Google Scholar]
- Toft H., Jespersen C. S. Meningitis forårsaget af gruppe B beta-haemolytiske streptokokker. Nord Med. 1968 Oct 17;80(42):1401–1402. [PubMed] [Google Scholar]
- Wallin J., Forsgren A. Group B streptococci in venereal disease clinic patients. Br J Vener Dis. 1975 Dec;51(6):401–404. doi: 10.1136/sti.51.6.401. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wheeler S. M., Foley G. E. A Note on Non-Group-A Streptococci Associated with Human Infection. J Bacteriol. 1943 Oct;46(4):391–392. doi: 10.1128/jb.46.4.391-392.1943. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wilkinson H. W., Eagon R. G. Type-specific antigens of group B type Ic streptococci. Infect Immun. 1971 Nov;4(5):596–604. doi: 10.1128/iai.4.5.596-604.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wilkinson H. W., Facklam R. R., Wortham E. C. Distribution by serological type of group B streptococci isolated from a variety of clinical material over a five-year period (with special reference to neonatal sepsis and meningitis). Infect Immun. 1973 Aug;8(2):228–235. doi: 10.1128/iai.8.2.228-235.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Winterbauer R. H., Fortuine R., Eickhoff T. C. Unusual occurrence of neonatal meningitis due to group B beta-hemolytic streptococci. Pediatrics. 1966 Oct;38(4):661–662. [PubMed] [Google Scholar]
- Zimmerman R. A., Hill H. R. Placental transfer of group A type-specific streptococcal antibody. Pediatrics. 1969 May;43(5):809–814. [PubMed] [Google Scholar]