Skip to main content
Postgraduate Medical Journal logoLink to Postgraduate Medical Journal
. 1977 Oct;53(624):598–606. doi: 10.1136/pgmj.53.624.598

Neonatal streptococcal infections.

M T Parker
PMCID: PMC2496775  PMID: 339212

Abstract

Most serious neonatal streptococcal infections are caused by group-B streptococci. The pattern of serious group-B neonatal disease in Britain resembles that described in other countries; both "early-onset" and "late-onset" forms are seen, but reliable incidence rates have not yet been determined. Serological-type III strains predominate in neonatal meningitis in Britain, but not so markedly as in some parts of the U.S.A. A deficiency of group-II strains in meningitis is, however, apparent in both countries. Present information about the carriage of group-B streptococci suggests that antibiotic prophylaxis administered to mothers or infants is unlikely to reduce greatly the frequency of "early-onset" disease. The continuous presence of a suitable chemical disinfectant in the vagina during labour might be more effective. Insufficient is known about the epidemiology of "late-onset" neonatal disease for rational preventive measures to be designed. More information is required about the postnatal acquisition of group-B streptococci by neonates and its sources, and about passive transfer of type-specific antibody from the mother to her child.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ablow R. C., Driscoll S. G., Effmann E. L., Gross I., Jolles C. J., Uauy R., Warshaw J. B. A comparison of early-onset group B steptococcal neonatal infection and the respiratory-distress syndrome of the newborn. N Engl J Med. 1976 Jan 8;294(2):65–70. doi: 10.1056/NEJM197601082940201. [DOI] [PubMed] [Google Scholar]
  2. Anthony B. F., Concepcion N. F. Group B streptococcus in a general hospital. J Infect Dis. 1975 Nov;132(5):561–567. doi: 10.1093/infdis/132.5.561. [DOI] [PubMed] [Google Scholar]
  3. BOISSARD J. M., ETON B. Neonatal umbilicus as a source of streptococcal infections in a maternity unit. Br Med J. 1956 Sep 8;2(4992):574–576. doi: 10.1136/bmj.2.4992.574. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Baker C. J., Barrett F. F. Group B streptococcal infections in infants. The importance of the various serotypes. JAMA. 1974 Nov 25;230(8):1158–1160. [PubMed] [Google Scholar]
  5. Baker C. J., Barrett F. F. Transmission of group B streptococci among parturient women and their neonates. J Pediatr. 1973 Dec;83(6):919–925. doi: 10.1016/s0022-3476(73)80524-4. [DOI] [PubMed] [Google Scholar]
  6. Baker C. J., Kasper D. L. Correlation of maternal antibody deficiency with susceptibility to neonatal group B streptococcal infection. N Engl J Med. 1976 Apr 1;294(14):753–756. doi: 10.1056/NEJM197604012941404. [DOI] [PubMed] [Google Scholar]
  7. Bret A. J., Durieux R. Méningite du nouveau-né et infection vaginale à streptocoque B. Diagnostic différentiel avec le pneumocoque saprophyte et pathogénicité. Rev Fr Gynecol Obstet. 1965 Dec;60(12):785–788. [PubMed] [Google Scholar]
  8. Brown J. H. Double-Zone Beta-Hemolytic Streptococci: Their Cultural Characteristics, Serological Grouping, Occurrence and Pathogenic Significance. J Bacteriol. 1939 Feb;37(2):133–144. doi: 10.1128/jb.37.2.133-144.1939. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Dolphin A., Cruickshank R. Penicillin Therapy in Acute Bacterial Endocarditis. Br Med J. 1945 Jun 30;1(4408):897–901. doi: 10.1136/bmj.1.4408.897. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. EICKHOFF T. C., KLEIN J. O., DALY A. K., INGALL D., FINLAND M. NEONATAL SEPSIS AND OTHER INFECTIONS DUE TO GROUP B BETA-HEMOLYTIC STREPTOCOCCI. N Engl J Med. 1964 Dec 10;271:1221–1228. doi: 10.1056/NEJM196412102712401. [DOI] [PubMed] [Google Scholar]
  11. Etienne M., Curioni S., Laplane R. La gravité des méningites bactériennes néonatales. Ann Pediatr (Paris) 1965 Jun-Jul;12(6):421–433. [PubMed] [Google Scholar]
  12. Ferrieri P., Cleary P. P., Seeds A. E. Epidemiology of group-B streptococcal carriage in pregnant women and newborn infants. J Med Microbiol. 1977 Feb;10(1):103–114. doi: 10.1099/00222615-10-1-103. [DOI] [PubMed] [Google Scholar]
  13. Finch R. G., French G. L., Phillips I. Group B streptococci in the female genital tract. Br Med J. 1976 May 22;1(6020):1245–1247. doi: 10.1136/bmj.1.6020.1245. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Franciosi R. A., Knostman J. D., Zimmerman R. A. Group B streptococcal neonatal and infant infections. J Pediatr. 1973 Apr;82(4):707–718. doi: 10.1016/s0022-3476(73)80604-3. [DOI] [PubMed] [Google Scholar]
  15. GRAY J. D. A. Outbreak of streptococcal infection in a maternity unit. Lancet. 1956 Jul 21;271(6934):132–136. [PubMed] [Google Scholar]
  16. HOOD M., JANNEY A., DAMERON G. Beta hemolytic streptococcus group B associated with problems of the perinatal period. Am J Obstet Gynecol. 1961 Oct;82:809–818. doi: 10.1016/s0002-9378(16)36146-4. [DOI] [PubMed] [Google Scholar]
  17. Hall W. H. Purpura fulminans with group B Beta-hemolytic streptococcal endocarditis. Arch Intern Med. 1965 Oct;116(4):594–597. [PubMed] [Google Scholar]
  18. Harper I. A. The importance of group B streptococci as human pathogens in the British Isles. J Clin Pathol. 1971 Jul;24(5):438–441. doi: 10.1136/jcp.24.5.438. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Howard J. B., McCracken G. H., Jr The spectrum of group B streptococcal infections in infancy. Am J Dis Child. 1974 Dec;128(6):815–818. doi: 10.1001/archpedi.1974.02110310063011. [DOI] [PubMed] [Google Scholar]
  20. JAMES J. R., KWANTES W. Haemolytic streptococci on the neonatal umbilicus. Br Med J. 1956 Sep 8;2(4992):576–578. doi: 10.1136/bmj.2.4992.576. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Jones H. E., Howells C. H. Neonatal meningitis due to Streptococcus agalactiae. Postgrad Med J. 1968 Jul;44(513):549–551. doi: 10.1136/pgmj.44.513.549. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. KAHLER J., AICHER J. Der Galtstreptokokkus als Erreger einer ulzero-polypösen Endokarditis beim Menschen. Zentralbl Allg Pathol. 1952 Mar-Apr;88(8-9):312–317. [PubMed] [Google Scholar]
  23. KEXEL G., SCHOENBOHM S. STREPTOCOCCUS AGALACTIAE ALS ERREGER VON SAEUGLINGSMENINGITIDEN. Dtsch Med Wochenschr. 1965 Feb 5;90:258–261. doi: 10.1055/s-0028-1111328. [DOI] [PubMed] [Google Scholar]
  24. Katzenstein A. L., Davis C., Braude A. Pulmonary changes in neonatal sepsis to group B beta-hemolytic Streptococcus: relation of hyaline membrane disease. J Infect Dis. 1976 Apr;133(4):430–435. doi: 10.1093/infdis/133.4.430. [DOI] [PubMed] [Google Scholar]
  25. Kexel G., Beck K. J. Untersuchungen über die Häufigkeit der B-Streptokokken im Wochenbett. Geburtshilfe Frauenheilkd. 1965 Nov;25(11):1078–1085. [PubMed] [Google Scholar]
  26. Kvittingen J. Beta-haemolytic Streptococcus group B causing neonatal meningitis. Acta Pathol Microbiol Scand. 1968;74(1):143–144. doi: 10.1111/j.1699-0463.1968.tb03465.x. [DOI] [PubMed] [Google Scholar]
  27. LANGEWISCH W. H. An epidemic of group A. type 1 streptococcal infections in newborn infants. Pediatrics. 1956 Sep;18(3):438–447. [PubMed] [Google Scholar]
  28. LAZARUS J. M., SELLERS D. P., MARINE W. M. MENINGITIS DUE TO THE GROUP B BETA-HEMOLYTIC STREPTOCOCCUS. N Engl J Med. 1965 Jan 21;272:146–147. doi: 10.1056/NEJM196501212720308. [DOI] [PubMed] [Google Scholar]
  29. Lafaix C., Duval J., Camerlynck P., Guérin M., Rey M. Méningite néonatale à streptocoque B (à propos de deux cas observés à Dakar) Bull Soc Med Afr Noire Lang Fr. 1968;13(1):181–183. [PubMed] [Google Scholar]
  30. Lancefield R. C. A SEROLOGICAL DIFFERENTIATION OF SPECIFIC TYPES OF BOVINE HEMOLYTIC STREPTOCOCCI (GROUP B). J Exp Med. 1934 Mar 31;59(4):441–458. doi: 10.1084/jem.59.4.441. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Lancefield R. C., Hare R. THE SEROLOGICAL DIFFERENTIATION OF PATHOGENIC AND NON-PATHOGENIC STRAINS OF HEMOLYTIC STREPTOCOCCI FROM PARTURIENT WOMEN. J Exp Med. 1935 Feb 28;61(3):335–349. doi: 10.1084/jem.61.3.335. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Lancefield R. C., McCarty M., Everly W. N. Multiple mouse-protective antibodies directed against group B streptococci. Special reference to antibodies effective against protein antigens. J Exp Med. 1975 Jul 1;142(1):165–179. doi: 10.1084/jem.142.1.165. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Lancefield R. C. TWO SEROLOGICAL TYPES OF GROUP B HEMOLYTIC STREPTOCOCCI WITH RELATED, BUT NOT IDENTICAL, TYPE-SPECIFIC SUBSTANCES. J Exp Med. 1938 Jan 1;67(1):25–40. doi: 10.1084/jem.67.1.25. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Maher E., Irwin R. C. Group B streptococcal infection in infancy: a case report and review. Pediatrics. 1966 Oct;38(4):659–661. [PubMed] [Google Scholar]
  35. Mathews J. H., Klesius P. H., Zimmerman R. A. Opsonin system of the group B streptococcus. Infect Immun. 1974 Dec;10(6):1315–1320. doi: 10.1128/iai.10.6.1315-1320.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. NYHAN W. L., FOUSEK M. D. Septicemia of the newborn. Pediatrics. 1958 Aug;22(2):268–278. [PubMed] [Google Scholar]
  37. PATTISON I. H., MATTHEWS P. R., MAXTED W. R. Type classification by Lancefield's precipitin method of human and bovine group-B streptococci isolated in Britain. J Pathol Bacteriol. 1955 Jan-Apr;69(1-2):43–50. doi: 10.1002/path.1700690108. [DOI] [PubMed] [Google Scholar]
  38. Parker M. T., Ball L. C. Streptococci and aerococci associated with systemic infection in man. J Med Microbiol. 1976 Aug;9(3):275–302. doi: 10.1099/00222615-9-3-275. [DOI] [PubMed] [Google Scholar]
  39. Quirante J., Ceballos R., Cassady G. Group B beta-hemolytic streptococcal infection in the newborn. I. Early onset infection. Am J Dis Child. 1974 Nov;128(5):659–665. doi: 10.1001/archpedi.1974.02110300069009. [DOI] [PubMed] [Google Scholar]
  40. REINARZ J. A., SANFORD J. P. HUMAN INFECTIONS CAUSED BY NON-GROUP A OR D STREPTOCOCCI. Medicine (Baltimore) 1965 Jan;44:81–96. doi: 10.1097/00005792-196501000-00003. [DOI] [PubMed] [Google Scholar]
  41. Reid T. M. Emergence of group B streptococci in obstetric and perinatal infections. Br Med J. 1975 Jun 7;2(5970):533–535. doi: 10.1136/bmj.2.5970.533. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Sicherman M. J. Septicemia due to group B streptococcus: report of two siblings presenting with lesions resembling erythema nodosum. Pediatrics. 1965 Dec;36(6):937–939. [PubMed] [Google Scholar]
  43. Steere A. C., Aber R. C., Warford L. R., Murphy K. E., Feeley J. C., Hayes P. S., Wilkinson H. W., Facklam R. R. Possible nosocomial transmission of group B streptococci in a newborn nursery. J Pediatr. 1975 Nov;87(5):784–787. doi: 10.1016/s0022-3476(75)80311-8. [DOI] [PubMed] [Google Scholar]
  44. Toft H., Jespersen C. S. Meningitis forårsaget af gruppe B beta-haemolytiske streptokokker. Nord Med. 1968 Oct 17;80(42):1401–1402. [PubMed] [Google Scholar]
  45. Wallin J., Forsgren A. Group B streptococci in venereal disease clinic patients. Br J Vener Dis. 1975 Dec;51(6):401–404. doi: 10.1136/sti.51.6.401. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. Wheeler S. M., Foley G. E. A Note on Non-Group-A Streptococci Associated with Human Infection. J Bacteriol. 1943 Oct;46(4):391–392. doi: 10.1128/jb.46.4.391-392.1943. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. Wilkinson H. W., Eagon R. G. Type-specific antigens of group B type Ic streptococci. Infect Immun. 1971 Nov;4(5):596–604. doi: 10.1128/iai.4.5.596-604.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. Wilkinson H. W., Facklam R. R., Wortham E. C. Distribution by serological type of group B streptococci isolated from a variety of clinical material over a five-year period (with special reference to neonatal sepsis and meningitis). Infect Immun. 1973 Aug;8(2):228–235. doi: 10.1128/iai.8.2.228-235.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. Winterbauer R. H., Fortuine R., Eickhoff T. C. Unusual occurrence of neonatal meningitis due to group B beta-hemolytic streptococci. Pediatrics. 1966 Oct;38(4):661–662. [PubMed] [Google Scholar]
  50. Zimmerman R. A., Hill H. R. Placental transfer of group A type-specific streptococcal antibody. Pediatrics. 1969 May;43(5):809–814. [PubMed] [Google Scholar]

Articles from Postgraduate Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES