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. 1977 Oct;53(624):588–591. doi: 10.1136/pgmj.53.624.588

Cytomegalovirus infection in the neonate and its prevention.

H Stern
PMCID: PMC2496782  PMID: 201930

Abstract

About 0.5% of infants are infected in utero with cytomegalovirus (CMV). As many as 20% become mentally retarded and a further substantial proportion suffer lesser degrees of brain damage. The need for a vaccine is greater than in the case of rubella. A live, tissue culture-adapted strain of CMV has been shown to produce neutralizing antibody in volunteers without significant side effects or detectable virus excretion. The problems of developing such a vaccine for use in man, namely, attenuation, antigenic differences among virus strains, reactivation of latent infection and oncogenicity, are briefly discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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