Abstract
The role of prostaglandins in inflammation is still disputed. Some workers have attempted to fit prostaglandins into a simple model, i.e. inflammatory leads to chemical mediator leads to vascular response. Recent work has shown that this approach may be misleading. An alternative model is proposed, involving the interaction of two chemical agents, i.e. a vascular permeability-increasing mediator (such as histamine or bradykinin) and a vasodilator (prostaglandin) which potentiates the plasma exudation produced by the permeability-increasing mediator. The results obtained in testing this model support the further proposal that non-steroidal anti-inflammatory compounds suppress inflammatory swelling by inhibiting vasodilatation.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Kuehl F. A., Jr, Humes J. L., Egan R. W., Ham E. A., Beveridge G. C., Van Arman C. G. Role of prostaglandin endoperoxide PGG2 in inflammatory processes. Nature. 1977 Jan 13;265(5590):170–173. doi: 10.1038/265170a0. [DOI] [PubMed] [Google Scholar]
- Moncada S., Ferreira S. H., Vane J. R. Prostaglandins, aspirin-like drugs and the oedema of inflammation. Nature. 1973 Nov 23;246(5430):217–219. doi: 10.1038/246217a0. [DOI] [PubMed] [Google Scholar]
- TRETHEWIE E. R. The influence of sodium salicylate and acetyl salicylic acid on the release of histamine in anaphylaxis. Aust J Exp Biol Med Sci. 1951 Nov;29(6):443–450. doi: 10.1038/icb.1951.50. [DOI] [PubMed] [Google Scholar]
- Thomas G., West G. B. Letter: Prostaglandins as regulators of bradykinin responses. J Pharm Pharmacol. 1973 Sep;25(9):747–748. doi: 10.1111/j.2042-7158.1973.tb10059.x. [DOI] [PubMed] [Google Scholar]
- Vane J. R. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol. 1971 Jun 23;231(25):232–235. doi: 10.1038/newbio231232a0. [DOI] [PubMed] [Google Scholar]
- Williams T. J., Morley J. Prostaglandins as potentiators of increased vascular permeability in inflammation. Nature. 1973 Nov 23;246(5430):215–217. doi: 10.1038/246215a0. [DOI] [PubMed] [Google Scholar]