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. 1990 Aug;64(8):3960–3962. doi: 10.1128/jvi.64.8.3960-3962.1990

Mutation Frequencies at Defined Single Codon Sites in Vesicular Stomatitis Virus and Poliovirus Can Be Increased Only Slightly by Chemical Mutagenesis

John J Holland 1,*, Esteban Domingo 1,†, Juan Carlos de la Torre 1, David A Steinhauer 1,‡
PMCID: PMC249691  PMID: 1695258

Abstract

Mutagenesis by a variety of chemical mutagens conferred only 1.1- to 2.8-fold increases in mutation frequencies at defined single base sites in vesicular stomatitis virus and poliovirus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Batschelet E., Domingo E., Weissmann C. The proportion of revertant and mutant phage in a growing population, as a function of mutation and growth rate. Gene. 1976;1(1):27–32. doi: 10.1016/0378-1119(76)90004-4. [DOI] [PubMed] [Google Scholar]
  2. CARP R. I., KOPROWSKI H. Mutation of type 3 poliovirus with nitrous acid. Virology. 1962 May;17:99–109. doi: 10.1016/0042-6822(62)90086-7. [DOI] [PubMed] [Google Scholar]
  3. Cupples C. G., Miller J. H. A set of lacZ mutations in Escherichia coli that allow rapid detection of each of the six base substitutions. Proc Natl Acad Sci U S A. 1989 Jul;86(14):5345–5349. doi: 10.1073/pnas.86.14.5345. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Domingo E., Flavell R. A., Weissmann C. In vitro site-directed mutagenesis: generation and properties of an infectious extracistronic mutant of bacteriophage Qbeta. Gene. 1976;1(1):3–25. doi: 10.1016/0378-1119(76)90003-2. [DOI] [PubMed] [Google Scholar]
  5. Fields B. N., Joklik W. K. Isolation and preliminary genetic and biochemical characterization of temperature-sensitive mutants of reovirus. Virology. 1969 Mar;37(3):335–342. doi: 10.1016/0042-6822(69)90217-7. [DOI] [PubMed] [Google Scholar]
  6. GRANOFF A. Induction of Newcastle disease virus mutants with nitrous acid. Virology. 1961 Apr;13:402–408. doi: 10.1016/0042-6822(61)90270-7. [DOI] [PubMed] [Google Scholar]
  7. Halle S. 5-Azacytidine as a mutagen for arboviruses. J Virol. 1968 Oct;2(10):1228–1229. doi: 10.1128/jvi.2.10.1228-1229.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Holland J. J., Villarreal L. P., Breindl M. Factors involved in the generation and replication of rhabdovirus defective T particles. J Virol. 1976 Mar;17(3):805–815. doi: 10.1128/jvi.17.3.805-815.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Holland J. J., de la Torre J. C., Steinhauer D. A., Clarke D., Duarte E., Domingo E. Virus mutation frequencies can be greatly underestimated by monoclonal antibody neutralization of virions. J Virol. 1989 Dec;63(12):5030–5036. doi: 10.1128/jvi.63.12.5030-5036.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. MUNDRY K. W., GIERER A. Die Erzeugung von Mutationen des Tabakmosaikvirus durch chemische Behandlung seiner Nucleinsäure in vitro. Z Vererbungsl. 1958;89(4):614–630. [PubMed] [Google Scholar]
  11. Pincus S. E., Rohl H., Wimmer E. Guanidine-dependent mutants of poliovirus: identification of three classes with different growth requirements. Virology. 1987 Mar;157(1):83–88. doi: 10.1016/0042-6822(87)90316-3. [DOI] [PubMed] [Google Scholar]
  12. Pringle C. R., Devine V., Wilkie M., Preston C. M., Dolan A., McGeoch D. J. Enhanced mutability associated with a temperature-sensitive mutant of vesicular stomatitis virus. J Virol. 1981 Aug;39(2):377–389. doi: 10.1128/jvi.39.2.377-389.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Pringle C. R. Genetic characteristics of conditional lethal mutants of vesicular stomatitis virus induced by 5-fluorouracil, 5-azacytidine, and ethyl methane sulfonate. J Virol. 1970 May;5(5):559–567. doi: 10.1128/jvi.5.5.559-567.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Radman M., Wagner R. Mismatch repair in Escherichia coli. Annu Rev Genet. 1986;20:523–538. doi: 10.1146/annurev.ge.20.120186.002515. [DOI] [PubMed] [Google Scholar]
  15. Smith D. B., Inglis S. C. The mutation rate and variability of eukaryotic viruses: an analytical review. J Gen Virol. 1987 Nov;68(Pt 11):2729–2740. doi: 10.1099/0022-1317-68-11-2729. [DOI] [PubMed] [Google Scholar]
  16. Steinhauer D. A., Holland J. J. Rapid evolution of RNA viruses. Annu Rev Microbiol. 1987;41:409–433. doi: 10.1146/annurev.mi.41.100187.002205. [DOI] [PubMed] [Google Scholar]
  17. Steinhauer D. A., de la Torre J. C., Holland J. J. High nucleotide substitution error frequencies in clonal pools of vesicular stomatitis virus. J Virol. 1989 May;63(5):2063–2071. doi: 10.1128/jvi.63.5.2063-2071.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Valcárcel J., Ortín J. Phenotypic hiding: the carryover of mutations in RNA viruses as shown by detection of mar mutants in influenza virus. J Virol. 1989 Sep;63(9):4107–4109. doi: 10.1128/jvi.63.9.4107-4109.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. de la Torre J. C., Wimmer E., Holland J. J. Very high frequency of reversion to guanidine resistance in clonal pools of guanidine-dependent type 1 poliovirus. J Virol. 1990 Feb;64(2):664–671. doi: 10.1128/jvi.64.2.664-671.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]

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