Abstract
Congestive heart failure constitutes one of the major causes of morbidity and mortality in Western countries. However, it is often misdiagnosed and the validity of the diagnosis is often difficult to establish. The clinical signs are not very sensitive and symptoms are nonspecific. Secretion of natriuretic peptides is increased in situations of cardiac overload. Testing the levels of these peptides, especially BNP and NT-proBNP, appears to offer a significant advance in the diagnosis and treatment of heart failure. In this article we would like to discuss the value of natriuretic peptides in congestive heart failure and give a short review of the literature.
Keywords: natriuretic peptides, congestive heart failure, review
Full text
PDF


Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Anand Inder S., Fisher Lloyd D., Chiang Yann-Tong, Latini Roberto, Masson Serge, Maggioni Aldo P., Glazer Robert D., Tognoni Gianni, Cohn Jay N., Val-HeFT Investigators Changes in brain natriuretic peptide and norepinephrine over time and mortality and morbidity in the Valsartan Heart Failure Trial (Val-HeFT). Circulation. 2003 Mar 11;107(9):1278–1283. doi: 10.1161/01.cir.0000054164.99881.00. [DOI] [PubMed] [Google Scholar]
- Clerico A., Iervasi G., Del Chicca M. G., Emdin M., Maffei S., Nannipieri M., Sabatino L., Forini F., Manfredi C., Donato L. Circulating levels of cardiac natriuretic peptides (ANP and BNP) measured by highly sensitive and specific immunoradiometric assays in normal subjects and in patients with different degrees of heart failure. J Endocrinol Invest. 1998 Mar;21(3):170–179. doi: 10.1007/BF03347297. [DOI] [PubMed] [Google Scholar]
- Cowie M. R., Struthers A. D., Wood D. A., Coats A. J., Thompson S. G., Poole-Wilson P. A., Sutton G. C. Value of natriuretic peptides in assessment of patients with possible new heart failure in primary care. Lancet. 1997 Nov 8;350(9088):1349–1353. doi: 10.1016/S0140-6736(97)06031-5. [DOI] [PubMed] [Google Scholar]
- Harrison Alex, Morrison L. Katherine, Krishnaswamy Padma, Kazanegra Radmila, Clopton Paul, Dao Quyen, Hlavin Patricia, Maisel Alan S. B-type natriuretic peptide predicts future cardiac events in patients presenting to the emergency department with dyspnea. Ann Emerg Med. 2002 Feb;39(2):131–138. doi: 10.1067/mem.2002.121483. [DOI] [PubMed] [Google Scholar]
- Kitzman Dalane W., Little William C., Brubaker Peter H., Anderson Roger T., Hundley W. Gregory, Marburger Christian T., Brosnihan Bridget, Morgan Timothy M., Stewart Kathryn P. Pathophysiological characterization of isolated diastolic heart failure in comparison to systolic heart failure. JAMA. 2002 Nov 6;288(17):2144–2150. doi: 10.1001/jama.288.17.2144. [DOI] [PubMed] [Google Scholar]
- Koglin J., Pehlivanli S., Schwaiblmair M., Vogeser M., Cremer P., vonScheidt W. Role of brain natriuretic peptide in risk stratification of patients with congestive heart failure. J Am Coll Cardiol. 2001 Dec;38(7):1934–1941. doi: 10.1016/s0735-1097(01)01672-2. [DOI] [PubMed] [Google Scholar]
- Levin E. R., Gardner D. G., Samson W. K. Natriuretic peptides. N Engl J Med. 1998 Jul 30;339(5):321–328. doi: 10.1056/NEJM199807303390507. [DOI] [PubMed] [Google Scholar]
- Masson Serge, Vago Tarcisio, Baldi Gabriella, Salio Monica, De Angelis Noeleen, Nicolis Enrico, Maggioni Aldo P., Latini Roberto, Norbiato Guido, Bevilacqua Maurizio. Comparative measurement of N-terminal pro-brain natriuretic peptide and brain natriuretic peptide in ambulatory patients with heart failure. Clin Chem Lab Med. 2002 Aug;40(8):761–763. doi: 10.1515/CCLM.2002.130. [DOI] [PubMed] [Google Scholar]
- McCullough Peter A., Omland Torbjørn, Maisel Alan S. B-type natriuretic peptides: a diagnostic breakthrough for clinicians. Rev Cardiovasc Med. 2003 Spring;4(2):72–80. [PubMed] [Google Scholar]
- Schweitz H., Vigne P., Moinier D., Frelin C., Lazdunski M. A new member of the natriuretic peptide family is present in the venom of the green mamba (Dendroaspis angusticeps). J Biol Chem. 1992 Jul 15;267(20):13928–13932. [PubMed] [Google Scholar]
- Troughton R. W., Frampton C. M., Yandle T. G., Espiner E. A., Nicholls M. G., Richards A. M. Treatment of heart failure guided by plasma aminoterminal brain natriuretic peptide (N-BNP) concentrations. Lancet. 2000 Apr 1;355(9210):1126–1130. doi: 10.1016/s0140-6736(00)02060-2. [DOI] [PubMed] [Google Scholar]
- Yamamoto K., Burnett J. C., Jr, Jougasaki M., Nishimura R. A., Bailey K. R., Saito Y., Nakao K., Redfield M. M. Superiority of brain natriuretic peptide as a hormonal marker of ventricular systolic and diastolic dysfunction and ventricular hypertrophy. Hypertension. 1996 Dec;28(6):988–994. doi: 10.1161/01.hyp.28.6.988. [DOI] [PubMed] [Google Scholar]
- Yoshimura M., Yasue H., Morita E., Sakaino N., Jougasaki M., Kurose M., Mukoyama M., Saito Y., Nakao K., Imura H. Hemodynamic, renal, and hormonal responses to brain natriuretic peptide infusion in patients with congestive heart failure. Circulation. 1991 Oct;84(4):1581–1588. doi: 10.1161/01.cir.84.4.1581. [DOI] [PubMed] [Google Scholar]
- de Bold A. J., Borenstein H. B., Veress A. T., Sonnenberg H. A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats. Life Sci. 1981 Jan 5;28(1):89–94. doi: 10.1016/0024-3205(81)90370-2. [DOI] [PubMed] [Google Scholar]
