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. 2004 Sep;12(9):389–393.

BEta versus Gamma Utrecht Trial-Cypher (BEGUT-CYPHER)

Is intracoronary brachytherapy still superior to drug-eluting stents?

PR Stella, P de Jaegere, JJ Battermann, P Bouma, MA Moerland, PA Doevendans
PMCID: PMC2497171  PMID: 25696369

Abstract

Design

Prospective, randomised single-centre pilot study comparing a beta with a gamma source and a sirolimus-eluting stent in patients with an estimated high risk of restenosis (40 to 50%).

Purpose

Although the majority of patients referred for revascularisation are now being treated with percutaneous coronary intervention (PCI) combined with stenting, a small number still suffer from recurrent restenosis which can be invalidating for the patient and frustrating for the cardiologist due to repeated PCIs.

In this prospective single-centre pilot study we will test the hypothesis of three different treatment strategies to use in this special patient subset, to determine if we can find a positive 'trend' in one arm, in order to either make a selection for one of the treatment strategies, or to provide a base to expand the study into a larger multicentre randomised study.

Time course and enrollment

A total of 120 patients will be included, 40 in each treatment arm. All patients with either in-stent and/or native restenosis and/or diabetics and/or type C lesions (ACC/AHA) are eligible. The usual exclusion criteria for intracoronary brachytherapy and prolonged antiplatelet therapy are applied. All lesions <44 mm in length and with a vessel diameter 2.4>4.0 mm are suitable. Angiographic, intravascular ultrasound imaging and clinical follow-up at one year will become available in the first quarter of 2005.

Keywords: brachytherapy, drug-eluting stents, PTCA, restenosis

Full text

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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