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. 1969 Feb;97(2):812–819. doi: 10.1128/jb.97.2.812-819.1969

Effect of Divalent Cations on the Uptake and Oxidation of Substrates by Pseudomonas aeruginosa

R G Eagon a, Mary A Asbell a,1
PMCID: PMC249765  PMID: 4975153

Abstract

Evidence is presented that Zn2+ and certain other multivalent cations inhibit the uptake and oxidation of substrates by Pseudomonas aeruginosa and by other bacterial cells. Tris(hydroxymethyl)aminomethane augmented this effect. Inhibition by these multivalent cations could be prevented by incubation of cellular suspensions of P. aeruginosa in phosphate buffer. In the case of other microorganisms, incubation in the presence of ethylenediaminetetraacetate also prevented the inhibition. Inhibition by Zn2+ of the uptake and of the oxidation of substrates could be reversed by the addition of Mg2+. Zn2+ was shown to inhibit noncompetitively the uptake of the three substrates studied, l-alanine, d-glucose, and citrate.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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