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Annals of The Royal College of Surgeons of England logoLink to Annals of The Royal College of Surgeons of England
. 1993 Jan;75(1):18–22.

Breast size and prognosis in early breast cancer.

A L Hoe 1, M A Mullee 1, G T Royle 1, P B Guyer 1, I Taylor 1
PMCID: PMC2497718  PMID: 8422138

Abstract

The influence of breast size on the prognosis of 196 patients with early breast cancer diagnosed in the period 1984-1985 was studied. Breast size was based on the volume from mammography. This method was validated against the volume of the mastectomy specimen determined by water displacement in 18 patients and found to be accurate (r = 0.93, P < 0.01). The median breast volume was 833.5 cm3 (interquartile range 522.8-1153.3 cm3). Breast size was significantly associated independently with age (Spearman's rank r = 0.24. P = 0.001), menstrual status (z = -4.81, P < 0.001), body weight (Spearman's rank r = 0.61, P < 0.001), T stage (z = -1.91, P = 0.05) but not N stage (z = -1.64, P = 0.10) or hormone receptor status (z = -0.80, P = 0.42). In an analysis of breast size and other known prognostic factors, based upon Cox's proportional hazards regression, N stage was the only significant factor for both breast cancer survival and disease-free survival. Even though women with larger tumours at presentation had larger breasts, breast size was not a significant prognostic factor in early breast cancer.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adami H. O., Rimsten A. Adipose tissue and aetiology of breast cancer. Lancet. 1978 Sep 23;2(8091):677–678. doi: 10.1016/s0140-6736(78)92784-8. [DOI] [PubMed] [Google Scholar]
  2. Beer A. E., Billingham R. E. Adipose tissue, a neglected factor in aetiology of breast cancer? Lancet. 1978 Aug 5;2(8084):296–296. doi: 10.1016/s0140-6736(78)91694-x. [DOI] [PubMed] [Google Scholar]
  3. Catchpole B. N. Breast size and cancer. Br Med J. 1977 Mar 19;1(6063):776–776. doi: 10.1136/bmj.1.6063.776-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Dupont W. D., Page D. L. Breast cancer risk associated with proliferative disease, age at first birth, and a family history of breast cancer. Am J Epidemiol. 1987 May;125(5):769–779. doi: 10.1093/oxfordjournals.aje.a114594. [DOI] [PubMed] [Google Scholar]
  5. Hebert J. R., Augustine A., Barone J., Kabat G. C., Kinne D. W., Wynder E. L. Weight, height and body mass index in the prognosis of breast cancer: early results of a prospective study. Int J Cancer. 1988 Sep 15;42(3):315–318. doi: 10.1002/ijc.2910420302. [DOI] [PubMed] [Google Scholar]
  6. Ingram D. M., Huang H. Y., Catchpole B. N., Roberts A. Do big breasts disadvantage women with breast cancer? Aust N Z J Surg. 1989 Feb;59(2):115–117. doi: 10.1111/j.1445-2197.1989.tb01479.x. [DOI] [PubMed] [Google Scholar]
  7. Katariya R. N., Forrest A. P., Gravelle I. H. Breast volumes in cancer of the breast. Br J Cancer. 1974 Mar;29(3):270–273. doi: 10.1038/bjc.1974.66. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Katch V. L., Campaigne B., Freedson P., Sady S., Katch F. I., Behnke A. R. Contribution of breast volume and weight to body fat distribution in females. Am J Phys Anthropol. 1980 Jul;53(1):93–100. doi: 10.1002/ajpa.1330530113. [DOI] [PubMed] [Google Scholar]
  9. Kolonel L. N., Nomura A. M., Lee J., Hirohata T. Anthropometric indicators of breast cancer risk in postmenopausal women in Hawaii. Nutr Cancer. 1986;8(4):247–256. doi: 10.1080/01635588609513901. [DOI] [PubMed] [Google Scholar]
  10. Lehrer S., Levine E., Song H. K., Bloomer W. D. Breast size, endogenous estrogens, and breast cancer: a review with hypothesis. Mt Sinai J Med. 1988 Mar;55(2):142–143. [PubMed] [Google Scholar]
  11. Senie R. T., Rosen P. P., Lesser M. L., Snyder R. E., Schottenfeld D., Duthie K. Epidemiology of breast carcinoma II: factors related to the predominance of left-sided disease. Cancer. 1980 Oct 1;46(7):1705–1713. doi: 10.1002/1097-0142(19801001)46:7<1705::aid-cncr2820460734>3.0.co;2-q. [DOI] [PubMed] [Google Scholar]
  12. Suissa S., Pollak M., Spitzer W. O., Margolese R. Body size and breast cancer prognosis: a statistical explanation of the discrepancies. Cancer Res. 1989 Jun 1;49(11):3113–3116. [PubMed] [Google Scholar]
  13. Valaoras V. G., MacMahon B., Trichopoulos D., Polychronopoulou A. Lactation and reproductive histories of breast cancer patients in greater Athens, 1965-67. Int J Cancer. 1969 May 15;4(3):350–363. doi: 10.1002/ijc.2910040312. [DOI] [PubMed] [Google Scholar]
  14. WYNDER E. L., BROSS I. J., HIRAYAMA T. A study of the epidemiology of cancer of the breast. Cancer. 1960 May-Jun;13:559–601. doi: 10.1002/1097-0142(196005/06)13:3<559::aid-cncr2820130322>3.0.co;2-0. [DOI] [PubMed] [Google Scholar]
  15. Ward C., Harrison B. The search for volumetric symmetry in reconstruction of the breast after mastectomy. Br J Plast Surg. 1986 Jul;39(3):379–385. doi: 10.1016/0007-1226(86)90052-4. [DOI] [PubMed] [Google Scholar]

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