Abstract
Preoperative mechanical bowel preparation, peroperative topical antiseptic measures, and postoperative antibiotic therapy have all been shown to reduce infection after colorectal surgery. We report the results of a randomised trial of preoperative irrigation with a 10% aqueous solution of povidone-iodine (Betadine) versus water in patients undergoing major resection for large bowel carcinoma. All patients had mechanical bowel preparation, preoperative topical povidone-iodine and per and postoperative antibiotics. Of 22 study patients only one (4.6%) developed abdominal wound infection, whereas in 23 controls nine (39.1%) did so (P less than 0.01). In three of the study patients cultures of swabs taken at operation from the transected bowel ends showed no bacterial growth. Arguably the bacterial population would have been markedly reduced in other patients. These results suggest that povidone-iodine irrigation before large bowel resection reduces wound sepsis.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Arango A., Lester J. L., 3rd, Martinez O. V., Malinin T. I., Zeppa R. Bacteriologic and systemic effects of intraoperative segmental bowel preparation with povidone iodine. Arch Surg. 1979 Feb;114(2):154–157. doi: 10.1001/archsurg.1979.01370260044006. [DOI] [PubMed] [Google Scholar]
- Beggs F. D., Jobanputra R. S., Holmes J. T. A comparison of intravenous and oral metronidazole as prophylactic in colorectal surgery. Br J Surg. 1982 Apr;69(4):226–227. doi: 10.1002/bjs.1800690419. [DOI] [PubMed] [Google Scholar]
- Jones F. E., DeCosse J. J., Condon R. E. Evaluation of "instant" preparation of the colon with povidone-iodine. Ann Surg. 1976 Jul;184(1):74–79. doi: 10.1097/00000658-197607000-00013. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LJUNGQVIST U. WOUND SEPSIS AFTER CLEAN OPERATIONS. Lancet. 1964 May 16;1(7342):1095–1097. doi: 10.1016/s0140-6736(64)91291-7. [DOI] [PubMed] [Google Scholar]
- Rees M., Ashby E. C., Pocock R. D., Dowding C. H. Povidone-iodine antisepsis for transrectal prostatic biopsy. Br Med J. 1980 Sep 6;281(6241):650–650. doi: 10.1136/bmj.281.6241.650. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sindelar W. F., Mason G. R. Intraperitoneal irrigation with povidone-iodine solution for the prevention of intra-abdominal abscesses in the bacterially contaminated abdomen. Surg Gynecol Obstet. 1979 Mar;148(3):409–411. [PubMed] [Google Scholar]