Skip to main content
PMC home page
Annals of The Royal College of Surgeons of England logoLink to Annals of The Royal College of Surgeons of England
. 1993 Nov;75(6):411–416.

Bile reflux in columnar-lined Barrett's oesophagus.

S Y Iftikhar 1, S Ledingham 1, R J Steele 1, D F Evans 1, K Lendrum 1, M Atkinson 1, J D Hardcastle 1
PMCID: PMC2498010  PMID: 8285543

Abstract

Total and individual bile acid concentrations in the oesophageal aspirates from 30 patients with Barrett's oesophagus were compared with those from 15 patients with oesophagitis and 15 normal subjects. The highest total bile acid concentrations were found in the Barrett's patients and this was statistically significant when compared with controls but not oesophagitis patients. However, when the 95th percentile value of bile acid concentration in the normal subjects was taken as the 'cut-off' level, a significantly higher number of Barrett's patients (15/30) were bile refluxers than were the oesophagitis patients (3/15). Glycocholic and taurocholic acids were the predominant bile acids detected, but taurochenodeoxycholic acid was also present in significant amounts in the patients with oesophagitis. It is possible that bile reflux contributes to the development of Barrett's oesophagus.

Full text

PDF
411

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Crumplin M. K., Stol D. W., Murphy G. M., Collis J. L. The pattern of bile salt reflux and acid secretion in sliding hiatal hernia. Br J Surg. 1974 Aug;61(8):611–616. doi: 10.1002/bjs.1800610806. [DOI] [PubMed] [Google Scholar]
  2. Dodds W. J. Instrumentation and methods for intraluminal esophageal manometry. Arch Intern Med. 1976 May;136(5):515–523. [PubMed] [Google Scholar]
  3. Gillen P., Keeling P., Byrne P. J., Healy M., O'Moore R. R., Hennessy T. P. Implication of duodenogastric reflux in the pathogenesis of Barrett's oesophagus. Br J Surg. 1988 Jun;75(6):540–543. doi: 10.1002/bjs.1800750612. [DOI] [PubMed] [Google Scholar]
  4. Gillen P., Keeling P., Byrne P. J., Hennessy T. P. Barrett's oesophagus: pH profile. Br J Surg. 1987 Sep;74(9):774–776. doi: 10.1002/bjs.1800740906. [DOI] [PubMed] [Google Scholar]
  5. Gillison E. W., De Castro V. A., Nyhus L. M., Kusakari K., Bombeck C. T. The significance of bile in reflux esophagitis. Surg Gynecol Obstet. 1972 Mar;134(3):419–424. [PubMed] [Google Scholar]
  6. Gotley D. C., Morgan A. P., Cooper M. J. Bile acid concentrations in the refluxate of patients with reflux oesophagitis. Br J Surg. 1988 Jun;75(6):587–590. doi: 10.1002/bjs.1800750632. [DOI] [PubMed] [Google Scholar]
  7. Hopwood D., Bateson M. C., Milne G., Bouchier I. A. Effects of bile acids and hydrogen ion on the fine structure of oesophageal epithelium. Gut. 1981 Apr;22(4):306–311. doi: 10.1136/gut.22.4.306. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kaye M. D., Showalter J. P. Manometric configuration of the lower esophageal sphincter in normal human subjects. Gastroenterology. 1971 Aug;61(2):213–223. [PubMed] [Google Scholar]
  9. Little A. G., Martinez E. I., DeMeester T. R., Blough R. M., Skinner D. B. Duodenogastric reflux and reflux esophagitis. Surgery. 1984 Aug;96(2):447–454. [PubMed] [Google Scholar]
  10. Meyer W., Vollmar F., Bär W. Barrett-esophagus following total gastrectomy. A contribution to it's pathogenesis. Endoscopy. 1979 May;11(2):121–126. doi: 10.1055/s-0028-1098335. [DOI] [PubMed] [Google Scholar]
  11. Mittal R. K., Reuben A., Whitney J. O., McCallum R. W. Do bile acids reflux into the esophagus? A study in normal subjects and patients with gastroesophageal reflux disease. Gastroenterology. 1987 Feb;92(2):371–375. doi: 10.1016/0016-5085(87)90130-2. [DOI] [PubMed] [Google Scholar]
  12. Moorehead R. J., Campbell G. R., Donaldson J. D., McKelvey S. T. Relationship between duodenal bile acids and colorectal neoplasia. Gut. 1987 Nov;28(11):1454–1459. doi: 10.1136/gut.28.11.1454. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Müller-Lissner S. A., Fimmel C. J., Sonnenberg A., Will N., Müller-Duysing W., Heinzel F., Müller R., Blum A. L. Novel approach to quantify duodenogastric reflux in healthy volunteers and in patients with type I gastric ulcer. Gut. 1983 Jun;24(6):510–518. doi: 10.1136/gut.24.6.510. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Rees W., Rhodes J. Bile reflux in gastro-oesophageal disease. Clin Gastroenterol. 1977 Jan;6(1):179–200. [PubMed] [Google Scholar]
  15. Safaie-Shirazi S., DenBesten L., Zike W. L. Effect of bile salts on the ionic permeability of the esophageal mucosa and their role in the production of esophagitis. Gastroenterology. 1975 Apr;68(4 Pt 1):728–733. [PubMed] [Google Scholar]

Articles from Annals of The Royal College of Surgeons of England are provided here courtesy of The Royal College of Surgeons of England

RESOURCES