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Annals of The Royal College of Surgeons of England logoLink to Annals of The Royal College of Surgeons of England
. 1986 Sep;68(5):286–289.

Haemorrhage and perforation of gastrointestinal neoplasms during chemotherapy.

J Randall, M L Obeid, G R Blackledge
PMCID: PMC2498310  PMID: 3491572

Abstract

Gastrointestinal haemorrhage and perforation are known complications of cytotoxic therapy for chemosensitive tumours involving the wall of the gut, in particular non-Hodgkin's lymphoma. These complications can be avoided by aggressive surgery before chemotherapy is started. When they do occur, early operative intervention is essential to reduce morbidity and mortality. We report 4 cases in whom delay in diagnosis and surgery led to 3 deaths and suggest a policy for the management of such cases in the future.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blackledge G., Bush H., Dodge O. G., Crowther D. A study of gastro-intestinal lymphoma. Clin Oncol. 1979 Sep;5(3):209–219. [PubMed] [Google Scholar]
  2. Fleming I. D., Mitchell S., Dilawari R. A. The role of surgery in the management of gastric lymphoma. Cancer. 1982 Mar 15;49(6):1135–1141. doi: 10.1002/1097-0142(19820315)49:6<1135::aid-cncr2820490612>3.0.co;2-e. [DOI] [PubMed] [Google Scholar]
  3. Goldman S. L., Pollak E. W., Wolfman E. F., Jr Massive upper gastrointestinal bleeding during chemotherapy for malignant melanoma. Am Surg. 1977 Nov;43(11):768–770. [PubMed] [Google Scholar]
  4. Gray G. M., Rosenberg S. A., Cooper A. D., Gregory P. B., Stein D. T., Herzenberg H. Lymphomas involving the gastrointestinal tract. Gastroenterology. 1982 Jan;82(1):143–152. [PubMed] [Google Scholar]
  5. Hande K. R., Fisher R. I., DeVita V. T., Chabner B. A., Young R. C. Diffuse histiocytic lymphoma involving the gastrointestinal tract. Cancer. 1978 May;41(5):1984–1989. doi: 10.1002/1097-0142(197805)41:5<1984::aid-cncr2820410544>3.0.co;2-8. [DOI] [PubMed] [Google Scholar]
  6. MORGAN M. W., SIGEL B., WOLCOTT M. W. Perforation of a metastatic carcinoma of the jejunum after cancer chemotherapy. Surgery. 1961 May;49:687–689. [PubMed] [Google Scholar]
  7. Meyers P. A., Potter V. P., Wollner N., Exelby P. Bowel perforation during initial treatment for childhood non-Hodgkin's lymphoma. Cancer. 1985 Jul 15;56(2):259–261. doi: 10.1002/1097-0142(19850715)56:2<259::aid-cncr2820560209>3.0.co;2-1. [DOI] [PubMed] [Google Scholar]
  8. Paulson S., Sheehan R. G., Stone M. J., Frenkel E. P. Large cell lymphomas of the stomach: improved prognosis with complete resection of all intrinsic gastrointestinal disease. J Clin Oncol. 1983 Apr;1(4):263–269. doi: 10.1200/JCO.1983.1.4.263. [DOI] [PubMed] [Google Scholar]
  9. Rosenfelt F., Rosenberg S. A. Diffuse histiocytic lymphoma presenting with gastrointestinal tract lesions. The Stanford experience. Cancer. 1980 Apr 15;45(8):2188–2193. doi: 10.1002/1097-0142(19800415)45:8<2188::aid-cncr2820450830>3.0.co;2-e. [DOI] [PubMed] [Google Scholar]
  10. SHERLOCK P., OROPEZAR Jejunal perforations in lymphoma after chemotherapy. Arch Intern Med. 1962 Jul;110:102–107. doi: 10.1001/archinte.1962.03620190104016. [DOI] [PubMed] [Google Scholar]
  11. Schlossberg D., Devig P. M., Travers H., Kovalcik P. J., Mullen J. T. Bowel perforation with candidiasis. JAMA. 1977 Dec 5;238(23):2520–2521. [PubMed] [Google Scholar]
  12. Steward W. P., Harris M., Wagstaff J., Scarffe J. H., Deakin D. P., Todd I. D., Crowther D. A prospective study of the treatment of high-grade histology non-Hodgkin's lymphoma involving the gastrointestinal tract. Eur J Cancer Clin Oncol. 1985 Oct;21(10):1195–1200. doi: 10.1016/0277-5379(85)90015-x. [DOI] [PubMed] [Google Scholar]
  13. Weingrad D. N., Decosse J. J., Sherlock P., Straus D., Lieberman P. H., Filippa D. A. Primary gastrointestinal lymphoma: a 30-year review. Cancer. 1982 Mar 15;49(6):1258–1265. doi: 10.1002/1097-0142(19820315)49:6<1258::aid-cncr2820490630>3.0.co;2-4. [DOI] [PubMed] [Google Scholar]

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