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. 1969 Mar;97(3):1234–1241. doi: 10.1128/jb.97.3.1234-1241.1969

Regulator Gene Controlling Enzymes Concerned in Tyrosine Biosynthesis in Escherichia coli

B J Wallace 1, James Pittard 1
PMCID: PMC249840  PMID: 4887504

Abstract

Mutants of Escherichia coli K-12 have been isolated in which several enzymes concerned with tyrosine biosynthesis are derepressed. These mutants were obtained from a parent strain possessing only a single 3-deoxy-d-arabinoheptulosonic acid-7-phosphate (DAHP) synthetase isoenzyme, DAHP synthetase (tyr), by selecting for resistance to the tyrosine analogue, 4-aminophenylalanine. The mutation responsible for this derepression has been mapped and the gene, which is not closely linked to aroF and tyrA, has been designated tyrR.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ADELBERG E. A., BURNS S. N. Genetic variation in the sex factor of Escherichia coli. J Bacteriol. 1960 Mar;79:321–330. doi: 10.1128/jb.79.3.321-330.1960. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BROWN K. D., DOY C. H. END-PRODUCT REGULATION OF THE GENERAL AROMATIC-PATHWAY IN ESCHERICHIA COLI W. Biochim Biophys Acta. 1963 Sep 3;77:170–172. doi: 10.1016/0006-3002(63)90489-x. [DOI] [PubMed] [Google Scholar]
  3. Brown K. D. Regulation of aromatic amino acid biosynthesis Escherichia coli K12. Genetics. 1968 Sep;60(1):31–48. doi: 10.1093/genetics/60.1.31. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. COTTON R. G., GIBSON F. THE BIOSYNTHESIS OF PHENYLALANINE AND TYROSINE; ENZYMES CONVERTING CHORISMIC ACID INTO PREPHENIC ACID AND THEIR RELATIONSHIPS TO PREPHENATE DEHYDRATASE AND PREPHENATE DEHYDROGENASE. Biochim Biophys Acta. 1965 Apr 12;100:76–88. doi: 10.1016/0304-4165(65)90429-0. [DOI] [PubMed] [Google Scholar]
  5. Doy C. H., Brown K. D. Control of aromatic biosynthesis: the multiplicity of 7-phospho-2-oxo-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating) in Escherichia coli W. Biochim Biophys Acta. 1965 Jul 8;104(2):377–389. doi: 10.1016/0304-4165(65)90343-0. [DOI] [PubMed] [Google Scholar]
  6. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  7. PITTARD J., ADELBERG E. A. GENE TRANSFER BY F' STRAINS OF ESCHERICHIA COLI K-12. III. AN ANALYSIS OF THE RECOMBINATION EVENTS OCCURRING IN THE F' MALE AND IN THE ZYGOTES. Genetics. 1964 Jun;49:995–1007. doi: 10.1093/genetics/49.6.995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Pittard J., Wallace B. J. Distribution and function of genes concerned with aromatic biosynthesis in Escherichia coli. J Bacteriol. 1966 Apr;91(4):1494–1508. doi: 10.1128/jb.91.4.1494-1508.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Ravel J. M., White M. N., Shive W. Activation of tyrosine analogs in relation to enzyme repression. Biochem Biophys Res Commun. 1965 Jul 26;20(3):352–359. doi: 10.1016/0006-291x(65)90372-4. [DOI] [PubMed] [Google Scholar]
  10. SILBERT D. F., JORGENSEN S. E., LIN E. C. Repression of transaminase A by tyrosine in Escherichia coli. Biochim Biophys Acta. 1963 Jun 11;73:232–240. doi: 10.1016/0006-3002(63)90307-x. [DOI] [PubMed] [Google Scholar]
  11. SMITH L. C., RAVEL J. M., LAX S. R., SHIVE W. THE EFFECTS OF PHENYLALANINE AND TYROSINE ANALOGS ON THE SYNTHESIS AND ACTIVITY OF 3-DEOXY-D-ARABINO-HEPTULOSONIC ACID 7-PHOSPHATE SYNTHETASES. Arch Biochem Biophys. 1964 May;105:424–430. doi: 10.1016/0003-9861(64)90026-8. [DOI] [PubMed] [Google Scholar]
  12. SMITH L. C., RAVEL J. M., LAX S. R., SHIVE W. The control of 3-deoxy-D-arabino-heptulosonic acid 7-phosphate synthesis by phenylalanine and tyrosine. J Biol Chem. 1962 Nov;237:3566–3570. [PubMed] [Google Scholar]
  13. Wallace B. J., Pittard J. Chromatography of 3-deoxy-D-arabinoheptulosonic acid-7-phosphate synthetase (trp) on diethylaminoethyl cellulose: a correction. J Bacteriol. 1967 Oct;94(4):1279–1280. doi: 10.1128/jb.94.4.1279-1280.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Wallace B. J., Pittard J. Genetic and biochemical analysis of the isoenzymes concerned in the first reaction of aromatic biosynthesis in Escherichia coli. J Bacteriol. 1967 Jan;93(1):237–244. doi: 10.1128/jb.93.1.237-244.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]

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