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. 1969 Mar;97(3):1283–1290. doi: 10.1128/jb.97.3.1283-1290.1969

Repression of the Histidine Operon: Effect of the First Enzyme on the Kinetics of Repression

John S Kovach a, M A Berberich a,1, Pál Venetianer a,2, Robert F Goldberger a
PMCID: PMC249845  PMID: 4887508

Abstract

Kinetic studies on repression of the enzymes for histidine biosynthesis in Salmonella typhimurium showed that, upon addition of histidine to a derepressed culture, the enzymes became repressed in a temporal sequence which corresponds with the positional sequence of the genes in the histidine operon. This serial pattern of repression occurred under conditions in which the feedback site of the first enzyme for histidine biosynthesis is intact. When this site was rendered nonfunctional the pattern of repression was changed so that all of the enzymes became repressed concomitantly. These results suggest that the first enzyme for histidine biosynthesis plays a hitherto unrecognized role in control of the histidine system.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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