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. 1969 Mar;97(3):1298–1304. doi: 10.1128/jb.97.3.1298-1304.1969

Cold-sensitive Mutations in Salmonella typhimurium Which Affect Ribosome Synthesis

Phang-Cheng Tai 1, Donald P Kessler 1, John Ingraham 1
PMCID: PMC249847  PMID: 4887510

Abstract

A number of mutations (45) expressed as cold-sensitive conditional lethal pheno-types were screened by transduction for their linkage to the streptomycin-resistance locus; 7 showed such linkage. Of these, two were studied in greater detail. The sedimentation profiles of ribosomes from cultures grown at low temperature differed from wild type and from one another. Both mutants lost ribonucleic acid control at low temperature. It is suggested that a high proportion of mutants expressing a cold-sensitive phenotype harbor mutations in genes affecting ribosome synthesis or regulation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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