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. 1987 May;69(3):100–103.

A relationship between perioperative blood transfusion and recurrence of carcinoma of the sigmoid colon following potentially curative surgery.

T S Creasy, P S Veitch, P R Bell
PMCID: PMC2498481  PMID: 3605994

Abstract

Preoperative blood transfusions are used to improve graft survival in renal transplantation. If such an immunomodulating effect occurred in cancer surgery perioperative blood transfusion may be detrimental to patient outcome. A retrospective study of 68 patients undergoing potentially curative surgery for adenocarcinoma of the sigmoid colon, over a 10 year period was performed. Thirty-three patients (49%) had a perioperative blood transfusion of which two-thirds received either one or two units. Transfused patients had a poorer prognosis compared to non-transfused patients (0.28 and 0.53 five year product limit recurrence free fractions respectively; P less than 0.01 on generalised Savege test of entire recurrence free curves). Perioperative transfusion was the most sensitive prognostic indicator of recurrence on Cox proportional hazards regression analysis (relative risk 2.6; P less than 0.01, after adjustment for histological stage). Although a causal relationship is not proven, prospective work is urgently needed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blumberg N., Agarwal M. M., Chuang C. Relation between recurrence of cancer of the colon and blood transfusion. Br Med J (Clin Res Ed) 1985 Apr 6;290(6474):1037–1039. doi: 10.1136/bmj.290.6474.1037. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Burrows L., Tartter P. Effect of blood transfusions on colonic malignancy recurrent rate. Lancet. 1982 Sep 18;2(8299):662–662. doi: 10.1016/s0140-6736(82)92764-7. [DOI] [PubMed] [Google Scholar]
  3. Fielding L. P. Red for danger: blood transfusion and colorectal cancer. Br Med J (Clin Res Ed) 1985 Sep 28;291(6499):841–842. doi: 10.1136/bmj.291.6499.841. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Foster R. S., Jr, Costanza M. C., Foster J. C., Wanner M. C., Foster C. B. Adverse relationship between blood transfusions and survival after colectomy for colon cancer. Cancer. 1985 Mar 15;55(6):1195–1201. doi: 10.1002/1097-0142(19850315)55:6<1195::aid-cncr2820550610>3.0.co;2-h. [DOI] [PubMed] [Google Scholar]
  5. Francis D., Judson R. Relation between recurrence of cancer of the colon and blood transfusion. Br Med J (Clin Res Ed) 1985 Aug 24;291(6494):544–544. doi: 10.1136/bmj.291.6494.544-b. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Frankish P. D., McNee R. K., Alley P. G., Woodfield D. G. Relation between cancer of the colon and blood transfusion. Br Med J (Clin Res Ed) 1985 Jun 15;290(6484):1827–1827. doi: 10.1136/bmj.290.6484.1827-b. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. KIRKLIN J. W., DOCKERTY M. B., WAUGH J. M. The role of the peritoneal reflection in the prognosis of carcinoma of the rectum and sigmoid colon. Surg Gynecol Obstet. 1949 Mar;88(3):326–331. [PubMed] [Google Scholar]
  8. Keown P. A., Descamps B. Improved renal allograft survival after blood transfusion: a nonspecific, erythrocyte-mediated immunoregulatory process? Lancet. 1979 Jan 6;1(8106):20–22. doi: 10.1016/s0140-6736(79)90458-6. [DOI] [PubMed] [Google Scholar]
  9. Opelz G., Sengar D. P., Mickey M. R., Terasaki P. I. Effect of blood transfusions on subsequent kidney transplants. Transplant Proc. 1973 Mar;5(1):253–259. [PubMed] [Google Scholar]
  10. Opelz G., Terasaki P. I. Improvement of kidney-graft survival with increased numbers of blood transfusions. N Engl J Med. 1978 Oct 12;299(15):799–803. doi: 10.1056/NEJM197810122991503. [DOI] [PubMed] [Google Scholar]
  11. Ota D., Alvarez L., Lichtiger B., Giacco G., Guinee V. Perioperative blood transfusion in patients with colon carcinoma. Transfusion. 1985 Jul-Aug;25(4):392–394. doi: 10.1046/j.1537-2995.1985.25485273825.x. [DOI] [PubMed] [Google Scholar]
  12. Terasaki P. I., Perdue S., Ayoub G., Iwaki Y., Park M. S., Mickey M. R. Reduction of accelerated failures by transfusion. Transplant Proc. 1982 Jun;14(2):251–259. [PubMed] [Google Scholar]
  13. Veitch P. S., Shenton B. K., Proud G., Taylor R. M. Plasma suppressive activity and kidney graft survival. Br J Surg. 1980 Oct;67(10):703–707. doi: 10.1002/bjs.1800671007. [DOI] [PubMed] [Google Scholar]
  14. Watson M. A., Briggs J. D., Diamandopoulos A. A., Hamilton D. N., Dick H. M. Endogenous cell-mediated immunity, blood transfusion, and outcome of renal transplantation. Lancet. 1979 Dec 22;2(8156-8157):1323–1326. doi: 10.1016/s0140-6736(79)92812-5. [DOI] [PubMed] [Google Scholar]
  15. van Es A. A., Balner H. Effect of pretransplant transfusions on kidney allograft survival. Transplant Proc. 1979 Mar;11(1):127–137. [PubMed] [Google Scholar]

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