Abstract
We studied prospectively 247 consecutive patients given morphine by continuous intravenous infusion for 24 h to provide pain relief following elective abdominal surgery. Using a dose of 1 mg/kg supplemented by additional intramuscular morphine 5 mg as necessary, only 26% required more than two additional intramuscular doses for discomfort. In 71 patients, the infusion was discontinued temporarily, mostly because of low respiratory rates. These patients were older (P less than 0.01), and their mean respiratory rate over the 24 h was significantly less (P less than 0.001) than those in whom the infusion was continuous. The technique was inexpensive, easy to use in a general surgical ward, and safe provided certain rules were observed.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Austin K. L., Stapleton J. V., Mather L. E. Relationship between blood meperidine concentrations and analgesic response: a preliminary report. Anesthesiology. 1980 Dec;53(6):460–466. doi: 10.1097/00000542-198012000-00005. [DOI] [PubMed] [Google Scholar]
- Catley D. M., Thornton C., Jordan C., Lehane J. R., Royston D., Jones J. G. Pronounced, episodic oxygen desaturation in the postoperative period: its association with ventilatory pattern and analgesic regimen. Anesthesiology. 1985 Jul;63(1):20–28. doi: 10.1097/00000542-198507000-00004. [DOI] [PubMed] [Google Scholar]
- Catling J. A., Pinto D. M., Jordan C., Jones J. G. Respiratory effects of analgesia after cholecystectomy: comparison of continuous and intermittent papaveretum. Br Med J. 1980 Aug 16;281(6238):478–480. doi: 10.1136/bmj.281.6238.478. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dodson M. E. A review of methods for relief of postoperative pain. Ann R Coll Surg Engl. 1982 Sep;64(5):324–327. [PMC free article] [PubMed] [Google Scholar]
- Handley A. J. Portable heparin injector. Lancet. 1970 Aug 8;2(7667):313–314. [PubMed] [Google Scholar]
- Hug C. C., Jr, Murphy M. R., Rigel E. P., Olson W. A. Pharmacokinetics of morphine injected intravenously into the anesthetized dog. Anesthesiology. 1981 Jan;54(1):38–47. doi: 10.1097/00000542-198101000-00008. [DOI] [PubMed] [Google Scholar]
- Jones J. G., Jordan C., Scudder C., Rocke D. A., Barrowcliffe M. Episodic postoperative oxygen desaturation: the value of added oxygen. J R Soc Med. 1985 Dec;78(12):1019–1022. doi: 10.1177/014107688507801208. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ngai S. H., Berkowitz B. A., Yang J. C., Hempstead J., Spector S. Pharmacokinetics of naloxone in rats and in man: basis for its potency and short duration of action. Anesthesiology. 1976 May;44(5):398–401. doi: 10.1097/00000542-197605000-00008. [DOI] [PubMed] [Google Scholar]
- Rutter P. C., Murphy F., Dudley H. A. Morphine: controlled trial of different methods of administration for postoperative pain relief. Br Med J. 1980 Jan 5;280(6206):12–13. doi: 10.1136/bmj.280.6206.12. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Vickers A. P., Derbyshire D. R., Burt D. R., Bagshaw P. F., Pearson H., Smith G. Comparison of the Leicester Micropalliator and the Cardiff Palliator in the relief of postoperative pain. Br J Anaesth. 1987 Apr;59(4):503–509. doi: 10.1093/bja/59.4.503. [DOI] [PubMed] [Google Scholar]
- Welchew E. A. On-demand analgesia. A double-blind comparison of on-demand intravenous fentanyl with regular intramuscular morphine. Anaesthesia. 1983 Jan;38(1):19–25. doi: 10.1111/j.1365-2044.1983.tb10367.x. [DOI] [PubMed] [Google Scholar]