Abstract
The purpose of this research was to establish the possible role of starch glove powder in complications following orthopaedic surgery using in vivo and in vitro techniques. Exposure of primary mouse peritoneal macrophages to starch glove powder caused 10% release of prostaglandin E2 (0.1 mg/ml, 16 h) but no increased release of lactate dehydrogenase, demonstrating that cell integrity had not been compromised. Long-term tissue reaction to starch glove powder was investigated in vivo by injection into mouse knee joints. Over a period of 52 weeks no inflammatory response was elicited, no starch was observed in the regional lymph nodes and none was found in joints after the 8th week. Starch glove powder appeared to be innocuous in the joint and although prostaglandin E2 release was stimulated in vitro, this had no apparent effect on joints in vivo.
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- Bjøro K., Stray-Pedersen S. Effects of vasoactive autacoids on different segments of human umbilicoplacental vessels. Gynecol Obstet Invest. 1986;22(1):1–6. doi: 10.1159/000298881. [DOI] [PubMed] [Google Scholar]
- Dean R. T., Hylton W., Allison A. C. Lysosomal enzyme secretion by macrophages during intracellular storage of particles. Biochim Biophys Acta. 1979 Apr 18;584(1):57–65. doi: 10.1016/0304-4165(79)90235-6. [DOI] [PubMed] [Google Scholar]
- Jaffray D. C., Nade S. Does surgical glove powder decrease the inoculum of bacteria required to produce an abscess? J R Coll Surg Edinb. 1983 Jul;28(4):219–222. [PubMed] [Google Scholar]
- MCADAMS G. B. Granulomata caused by absorbable starch glove powder. Surgery. 1956 Feb;39(2):329–336. [PubMed] [Google Scholar]
- Olson R. J., Wander A. H. Glove powder and corneal inflammation. Ann Ophthalmol. 1981 Jun;13(6):725–726. [PubMed] [Google Scholar]
- Rae T. A study on the effects of particulate metals of orthopaedic interest on murine macrophages in vitro. J Bone Joint Surg Br. 1975 Nov;57(4):444–450. [PubMed] [Google Scholar]
- Rae T. The biological response to titanium and titanium-aluminium-vanadium alloy particles. I. Tissue culture studies. Biomaterials. 1986 Jan;7(1):30–36. doi: 10.1016/0142-9612(86)90085-2. [DOI] [PubMed] [Google Scholar]
- Rae T. The biological response to titanium and titanium-aluminium-vanadium alloy particles. II. Long-term animal studies. Biomaterials. 1986 Jan;7(1):37–40. doi: 10.1016/0142-9612(86)90086-4. [DOI] [PubMed] [Google Scholar]
- Rae T. Tolerance of mouse macrophages in vitro to barium sulfate used in orthopedic bone cement. J Biomed Mater Res. 1977 Nov;11(6):839–846. doi: 10.1002/jbm.820110604. [DOI] [PubMed] [Google Scholar]
- Reikerås O., Nordstrand K. Use of dextran to prevent intraperitoneal adhesions caused by maize starch powder. Eur Surg Res. 1985;17(4):251–253. doi: 10.1159/000128474. [DOI] [PubMed] [Google Scholar]
- Rushton N., Rae T. The intra-articular response to particulate carbon fibre reinforced high density polyethylene and its constituents: an experimental study in mice. Biomaterials. 1984 Nov;5(6):352–356. doi: 10.1016/0142-9612(84)90034-6. [DOI] [PubMed] [Google Scholar]
- Singh I., Chow W. L., Chablani L. V. Synovial reaction to glove powder. Clin Orthop Relat Res. 1974 Mar-Apr;(99):285–292. doi: 10.1097/00003086-197403000-00031. [DOI] [PubMed] [Google Scholar]
- WROBLEWSKI F., LADUE J. S. Lactic dehydrogenase activity in blood. Proc Soc Exp Biol Med. 1955 Oct;90(1):210–213. doi: 10.3181/00379727-90-21985. [DOI] [PubMed] [Google Scholar]
- Wilson D. F., Garach V. Surgical glove starch granuloma. Oral Surg Oral Med Oral Pathol. 1981 Apr;51(4):342–345. doi: 10.1016/0030-4220(81)90139-0. [DOI] [PubMed] [Google Scholar]
- Yaffe H., Reinhartz T., Laufer N., Beyth Y. Potentially deleterious effect of cornstarch glove powder in tubal reconstructive surgery. Fertil Steril. 1978 Jun;29(6):699–701. doi: 10.1016/s0015-0282(16)43349-2. [DOI] [PubMed] [Google Scholar]