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. 1985 Sep;67(5):295–298.

Tumour angiogenesis.

F Arnold
PMCID: PMC2499524  PMID: 2413796

Abstract

Tumours induce the growth of host blood vessels to support their proliferation. This process of angiogenesis is evoked by specific chemical signals. Recognition of these angiogenic factors has led to experimental methods for cancer diagnosis and for inhibiting malignant growth by specifically blocking neovascularisation. The clinical potential of these techniques is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brem H., Folkman J. Inhibition of tumor angiogenesis mediated by cartilage. J Exp Med. 1975 Feb 1;141(2):427–439. doi: 10.1084/jem.141.2.427. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Eisenstein R., Schumacher B., Meineke C., Matijevitch B., Kuettner K. E. Growth regulators in connective tissue. Systemic administration of an aortic extract inhibits tumor growth in mice. Am J Pathol. 1978 Apr;91(1):1–9. [PMC free article] [PubMed] [Google Scholar]
  3. Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med. 1971 Nov 18;285(21):1182–1186. doi: 10.1056/NEJM197111182852108. [DOI] [PubMed] [Google Scholar]
  4. GULLINO P. M., GRANTHAM F. H. Studies on the exchange of fluids between host and tumor. III. Regulation of blood flow in hepatomas and other rat tumors. J Natl Cancer Inst. 1962 Jan;28:211–229. [PubMed] [Google Scholar]
  5. Greenblatt M., Shubi P. Tumor angiogenesis: transfilter diffusion studies in the hamster by the transparent chamber technique. J Natl Cancer Inst. 1968 Jul;41(1):111–124. [PubMed] [Google Scholar]
  6. Gullino P. M. Natural history of breast cancer. Progression from hyperplasia to neoplasia as predicted by angiogenesis. Cancer. 1977 Jun;39(6 Suppl):2697–2703. doi: 10.1002/1097-0142(197706)39:6<2697::aid-cncr2820390656>3.0.co;2-4. [DOI] [PubMed] [Google Scholar]
  7. HUGHES L. E. TREATMENT OF MALIGNANT DISEASE WITH PROTAMINE SULPHATE. Lancet. 1964 Feb 22;1(7330):408–409. doi: 10.1016/s0140-6736(64)92787-4. [DOI] [PubMed] [Google Scholar]
  8. Kumar P., Kumar S., Marsden H. B., Lynch P. G., Earnshaw E. Weibel-Palade bodies in endothelial cells as a marker for angiogenesis in brain tumors. Cancer Res. 1980 Jun;40(6):2010–2019. [PubMed] [Google Scholar]
  9. Kumar S., West D., Daniel M., Hancock A., Carr T. Human lung tumour cell line adapted to grow in serum-free medium secretes angiogenesis factor. Int J Cancer. 1983 Oct 15;32(4):461–464. doi: 10.1002/ijc.2910320412. [DOI] [PubMed] [Google Scholar]
  10. Langer R., Conn H., Vacanti J., Haudenschild C., Folkman J. Control of tumor growth in animals by infusion of an angiogenesis inhibitor. Proc Natl Acad Sci U S A. 1980 Jul;77(7):4331–4335. doi: 10.1073/pnas.77.7.4331. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Le Serve A. W., Hellmann K. Metastases and the normalization of tumour blood vessels by ICRF 159: a new type of drug action. Br Med J. 1972 Mar 4;1(5800):597–601. doi: 10.1136/bmj.1.5800.597. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Maciag T., Mehlman T., Friesel R., Schreiber A. B. Heparin binds endothelial cell growth factor, the principal endothelial cell mitogen in bovine brain. Science. 1984 Aug 31;225(4665):932–935. doi: 10.1126/science.6382607. [DOI] [PubMed] [Google Scholar]
  13. Nicosia R. F., Tchao R., Leighton J. Angiogenesis-dependent tumor spread in reinforced fibrin clot culture. Cancer Res. 1983 May;43(5):2159–2166. [PubMed] [Google Scholar]
  14. O'MEARA R. A., O'HALLORAN M. J. PROTAMINE DERIVATIVES IN TREATMENT OF ADVANCED CARCINOMA OF THE BREAST. Lancet. 1963 Sep 21;2(7308):613–614. doi: 10.1016/s0140-6736(63)90400-8. [DOI] [PubMed] [Google Scholar]
  15. Peterson H. I. Effects of prostaglandin synthesis inhibitors on tumor growth and vascularization. Experimental studies in the rat. Invasion Metastasis. 1983;3(3):151–159. [PubMed] [Google Scholar]
  16. Pitas R. E., Boyles J., Mahley R. W., Bissell D. M. Uptake of chemically modified low density lipoproteins in vivo is mediated by specific endothelial cells. J Cell Biol. 1985 Jan;100(1):103–117. doi: 10.1083/jcb.100.1.103. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Shahabuddin S., Arnold F., Costello C. B., Kumar S. Tumour angiogenesis factor in urological cancers. Br J Urol. 1984 Oct;56(5):490–494. [PubMed] [Google Scholar]
  18. THOMLINSON R. H., GRAY L. H. The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer. 1955 Dec;9(4):539–549. doi: 10.1038/bjc.1955.55. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Tapper D., Langer R., Bellows A. R., Folkman J. Angiogenesis capacity as a diagnostic marker for human eye tumors. Surgery. 1979 Jul;86(1):36–40. [PubMed] [Google Scholar]
  20. Taylor S., Folkman J. Protamine is an inhibitor of angiogenesis. Nature. 1982 May 27;297(5864):307–312. doi: 10.1038/297307a0. [DOI] [PubMed] [Google Scholar]
  21. URBACH F., GRAHAM J. H. Anatomy of human skin tumour capillaries. Nature. 1962 May 19;194:652–654. doi: 10.1038/194652a0. [DOI] [PubMed] [Google Scholar]
  22. Zetter B. R. Migration of capillary endothelial cells is stimulated by tumour-derived factors. Nature. 1980 May 1;285(5759):41–43. doi: 10.1038/285041a0. [DOI] [PubMed] [Google Scholar]

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