Skip to main content
Journal of Bacteriology logoLink to Journal of Bacteriology
. 1969 Jul;99(1):336–338. doi: 10.1128/jb.99.1.336-338.1969

Amino Acid Antagonist Death in Escherichia coli

M Rabinovitz 1, A Finkleman 1, R L Reagan 1, T R Breitman 1
PMCID: PMC250007  PMID: 4895850

Abstract

Six analogues of amino acids killed corresponding auxotrophs of Escherichia coli. With all but one analogue, protein synthesis was required for lethality.

Full text

PDF
336

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. DAVIS B. D., MINGIOLI E. S. Mutants of Escherichia coli requiring methionine or vitamin B12. J Bacteriol. 1950 Jul;60(1):17–28. doi: 10.1128/jb.60.1.17-28.1950. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. DITTMER K. The structural bases of some amino acid antagonists and their microbiological properties. Ann N Y Acad Sci. 1950 Jul 7;52(8):1274–1301. doi: 10.1111/j.1749-6632.1950.tb54030.x. [DOI] [PubMed] [Google Scholar]
  3. Das H. K., Goldstein A., Kanner L. C. Inhibition by chlorampenicol of the growth of nascent protein chains in Escherichia coli. Mol Pharmacol. 1966 Mar;2(2):158–170. [PubMed] [Google Scholar]
  4. Fowden L., Lewis D., Tristram H. Toxic amino acids: their action as antimetabolites. Adv Enzymol Relat Areas Mol Biol. 1967;29:89–163. doi: 10.1002/9780470122747.ch3. [DOI] [PubMed] [Google Scholar]
  5. GIBBONS I. R., GRIMSTONE A. V. On flagellar structure in certain flagellates. J Biophys Biochem Cytol. 1960 Jul;7:697–716. doi: 10.1083/jcb.7.4.697. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. KELLENBERGER E., RYTER A., SECHAUD J. Electron microscope study of DNA-containing plasms. II. Vegetative and mature phage DNA as compared with normal bacterial nucleoids in different physiological states. J Biophys Biochem Cytol. 1958 Nov 25;4(6):671–678. doi: 10.1083/jcb.4.6.671. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. NOVICK R. P., MAAS W. K. Control by endogenously synthesized arginine of the formation of ornithine transcarbamylase in Escherichia coli. J Bacteriol. 1961 Feb;81:236–240. doi: 10.1128/jb.81.2.236-240.1961. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. PARDEE A. B., PRESTIDGE L. S. Effects of azatryptophan on bacterial enzymes and bacteriophage. Biochim Biophys Acta. 1958 Feb;27(2):330–344. doi: 10.1016/0006-3002(58)90340-8. [DOI] [PubMed] [Google Scholar]
  9. REYNOLDS E. S. The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J Cell Biol. 1963 Apr;17:208–212. doi: 10.1083/jcb.17.1.208. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. RICHMOND M. H. The effect of amino acid analogues on growth and protein synthesis in microorganisms. Bacteriol Rev. 1962 Dec;26:398–420. doi: 10.1128/br.26.4.398-420.1962. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. SMITH S. S., BAYLISS N. L., MCCORD T. J. THE SYNTHESIS AND BIOLOGICAL ACTIVITIES OF SOME AZA ANALOGS OF AMINO ACIDS. I. 4-AZALEUCINE, AN INHIBITORY ANALOG OF LEUCINE. Arch Biochem Biophys. 1963 Aug;102:313–315. doi: 10.1016/0003-9861(63)90185-1. [DOI] [PubMed] [Google Scholar]
  12. Schachtele C. F., Anderson D. L., Rogers P. Mechanism of canavanine death in Escherichia coli. II. Membranes-bound canavanyl-protein and nuclear disruption. J Mol Biol. 1968 May 14;33(3):861–872. doi: 10.1016/0022-2836(68)90324-0. [DOI] [PubMed] [Google Scholar]
  13. Schachtele C. F., Rogers P. Canavanine death in Escherichia coli. J Mol Biol. 1965 Dec;14(2):474–489. doi: 10.1016/s0022-2836(65)80197-8. [DOI] [PubMed] [Google Scholar]
  14. Smulson M. E., Rabinovitz M., Breitman T. R. O-methylthreonine inhibition of growth and of threonine deaminase in Escherichia coli. J Bacteriol. 1967 Dec;94(6):1890–1895. doi: 10.1128/jb.94.6.1890-1895.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Unger L., DeMoss R. D. Action of a proline analogue, l-thiazolidine-4-carboxylic acid, in Escherichia coli. J Bacteriol. 1966 Apr;91(4):1556–1563. doi: 10.1128/jb.91.4.1556-1563.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. VAUGHAN M., STEINBERG D. The specificity of protein biosynthesis. Adv Protein Chem. 1959;14:115–173. doi: 10.1016/s0065-3233(08)60610-5. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Bacteriology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES