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. 1969 Aug;99(2):459–462. doi: 10.1128/jb.99.2.459-462.1969

Correlation Between Growth Inhibition and the Binding of Various Penicillins and Cephalosporins to Staphylococcus aureus

John R Edwards a,1, James T Park a
PMCID: PMC250038  PMID: 5808073

Abstract

The concentration of penicillin (or cephalosporin) required to achieve a given rate of binding to Staphylococcus aureus H correlates well with that required for inhibition of growth. This result suggests that the irreversible binding of penicillins and cephalosporins to cells is responsible for their biological activity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CHATTERJEE A. N., PARK J. T. BIOSYNTHESIS OF CELL WALL MUCOPEPTIDE BY A PARTICULATE FRACTION FROM STAPHYLOCOCCUS AUREUS. Proc Natl Acad Sci U S A. 1964 Jan;51:9–16. doi: 10.1073/pnas.51.1.9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. COOPER P. D., CLOWES R. C., ROWLEY D. A note on the use of radioactive penicillin. J Gen Microbiol. 1954 Apr;10(2):246–249. doi: 10.1099/00221287-10-2-246. [DOI] [PubMed] [Google Scholar]
  3. COOPER P. D. Site of action of radiopenicillin. Bacteriol Rev. 1956 Mar;20(1):28–48. doi: 10.1128/br.20.1.28-48.1956. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. COOPER P. D. The association of the penicillin-binding component of Staphylococcus aureus with a lipid fraction. J Gen Microbiol. 1954 Apr;10(2):236–245. doi: 10.1099/00221287-10-2-236. [DOI] [PubMed] [Google Scholar]
  5. COOPER P. D. The site of action of penicillin: some properties of the penicillin-binding component of Staphylococcus aureus. J Gen Microbiol. 1955 Feb;12(1):100–106. doi: 10.1099/00221287-12-1-100. [DOI] [PubMed] [Google Scholar]
  6. DANIEL J. W., Jr, JOHNSON M. J. Properties of the penicillin binding component of Micrococcus pyogenes. J Bacteriol. 1954 Mar;67(3):321–328. doi: 10.1128/jb.67.3.321-328.1954. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. EAGLE H. The binding of penicillin in relation to its cytotoxic action. I. Correlation between the penicillin sensitivity and combining activity of intact bacteria and cell-free extracts. J Exp Med. 1954 Mar;99(3):207–226. doi: 10.1084/jem.99.3.207. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. EAGLE H. The binding of penicillin in relation to its cytotoxic action. II. The reactivity with penicillin of resistant variants of streptococci, pneumococci, and staphylococci. J Exp Med. 1954 Jul 1;100(1):103–115. doi: 10.1084/jem.100.1.103. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Izaki K., Matsuhashi M., Strominger J. L. Glycopeptide transpeptidase and D-alanine carboxypeptidase: penicillin-sensitive enzymatic reactions. Proc Natl Acad Sci U S A. 1966 Mar;55(3):656–663. doi: 10.1073/pnas.55.3.656. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Maass E. A., Johnson M. J. PENICILLIN UPTAKE BY BACTERIAL CELLS. J Bacteriol. 1949 Apr;57(4):415–422. doi: 10.1128/jb.57.4.415-422.1949. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. ROGERS H. J., JELJASZEWICZ J. Inhibition of the biosynthesis of cell-wall mucopeptides by the penicillins. A study of penicillin-sensitive and penicillin-resistant strains of Staphylococcus aureus. Biochem J. 1961 Dec;81:576–584. doi: 10.1042/bj0810576. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Rowley D., Cooper P. D., Roberts P. W. The site of action of penicillin. 1. Uptake of penicillin on bacteria. Biochem J. 1950 Feb;46(2):157–161. doi: 10.1042/bj0460157. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. SCHEPARTZ S. A., JOHNSON M. J. The nature of the binding of penicillin by bacterial cells. J Bacteriol. 1956 Jan;71(1):84–90. doi: 10.1002/path.1700710112. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Tipper D. J., Strominger J. L. Mechanism of action of penicillins: a proposal based on their structural similarity to acyl-D-alanyl-D-alanine. Proc Natl Acad Sci U S A. 1965 Oct;54(4):1133–1141. doi: 10.1073/pnas.54.4.1133. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Wise E. M., Jr, Park J. T. Penicillin: its basic site of action as an inhibitor of a peptide cross-linking reaction in cell wall mucopeptide synthesis. Proc Natl Acad Sci U S A. 1965 Jul;54(1):75–81. doi: 10.1073/pnas.54.1.75. [DOI] [PMC free article] [PubMed] [Google Scholar]

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