Abstract
Adenosine-3′,5′-cyclic monophosphate was shown to be the compound found in Escherichia coli responsible for the attraction of the amoebae of the cellular slime mold Dictyostelium discoideum. A number of other nucleotides were tested and the following were active: tubercidin-3′,5′-cyclic monophosphate, N6-2′-O-dibutyryl-adenosine-3′,5′-cyclic monophosphate, 5′-methylene adenosine-3′,5′-cyclic monophosphonate, guanosine-3′,5′-cyclic monophosphate, uridine-3′,5′-cyclic monophosphate, cytidine-3′,5′-cyclic monophosphate, inosine-3′,5′-cyclic monophosphate, and thymidine-3′,5′-cyclic monophosphate. They were less active than adenosine-3′,5′-cyclic monophosphate. It is suggested that cyclic adenosine monophosphate secreted by the bacteria is used by the amoebae as a means of sensing and orienting towards food.
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Selected References
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