Abstract
The antigenic relationship between Brucella species and Vibrio cholerae was examined by agglutinin and agglutinin-absorption tests by using rabbit antisera. Brucella antisera agglutinated only the Inaba serotype of V. cholerae and at low titer. Inaba-reactive antibody was absorbed by either heat-stable (100 C, 2 hr) Ogawa or Inaba O antigens. Cholera antisera from rabbits immunized with either O or HO antigens of either Ogawa or Inaba serotypes contained brucella agglutinins. This activity was absorbed completely from Ogawa antisera by either Ogawa or Inaba O antigens but only partially from Inaba antisera by Ogawa O antigen. These findings support the claim of Gallut that the cross-reaction is due to heat-stable O antigens of V. cholerae rather than heat-labile flagellar antigens as described in many text books. The cross-reactive component is more dominant in the Inaba than in the Ogawa serotype of V. cholerae.
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- BURROWS W., POLLITZER R. Laboratory diagnosis of cholera. Bull World Health Organ. 1958;18(3):275–290. [PMC free article] [PubMed] [Google Scholar]
- GALLUT J. Relations antigéniques entre Vibrion cholérique et Brucelles. Ann Inst Pasteur (Paris) 1950 Sep;79(3):335–338. [PubMed] [Google Scholar]
- GALLUT J. Relations antigéniques entre vibrion cholérique et brucelles. II. Sur la fraction antigénique thermostable commune. Ann Inst Pasteur (Paris) 1953 Aug;85(2):261–262. [PubMed] [Google Scholar]
- GOODNER K., SMITH H. L., Jr, STEMPEN H. Serologic diagnosis of cholera. J Albert Einstein Med Cent (Phila) 1960 Apr;8:143–147. [PubMed] [Google Scholar]
- Mosley W. H., Ahmad S., Benenson A. S., Ahmed A. The relationship of vibriocidal antibody titre to susceptibility to cholera in family contacts of cholera patients. Bull World Health Organ. 1968;38(5):777–785. [PMC free article] [PubMed] [Google Scholar]
- Mosley W. H., Benenson A. S., Barui R. A serological survey for cholear antibodies in rural east Pakistan. 1. The distribution of antibody in the control population of a cholera-vaccine field-trial area and the relation of antibody titre to the pattern of endemic cholera. Bull World Health Organ. 1968;38(3):327–334. [PMC free article] [PubMed] [Google Scholar]
- Mosley W. H., Benenson A. S., Barui R. A serological survey for cholera antibodies in rural east Pakistan. 2. A comparison of antibody titres in the innunized and control populationd of a cholera-vaccine field-trial area and the relation of antibody titre to cholera case rate. Bull World Health Organ. 1968;38(3):335–346. [PMC free article] [PubMed] [Google Scholar]
- SPINK W. W., McCULLOUGH N. B., HUTCHINGS L. M., MINGLE C. K. A standardized antigen and agglutination technic for human brucellosis. Am J Clin Pathol. 1954 Apr;24(4):496–498. doi: 10.1093/ajcp/24.4_ts.496. [DOI] [PubMed] [Google Scholar]