Abstract
Both in vivo and in vitro experiments on wild-type Escherichia coli K-12 and mutant strains possessing only single 3-deoxy-d-arabino-heptulosonic 7-phosphate acid (DAHP) synthetase isoenzymes indicated that, under conditions when all three isoenzymes are fully repressed, sufficient chorismate is still formed for the synthesis of aromatic vitamins. Under repressed conditions both DAHP synthetase (phe) and (trp), but not DAHP synthetase (tyr), were shown to contribute to vitamin production.
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- BROWN K. D., DOY C. H. END-PRODUCT REGULATION OF THE GENERAL AROMATIC-PATHWAY IN ESCHERICHIA COLI W. Biochim Biophys Acta. 1963 Sep 3;77:170–172. doi: 10.1016/0006-3002(63)90489-x. [DOI] [PubMed] [Google Scholar]
- Cox G. B., Gibson F. 2,3-Dihydroxybenzoic acid, a new growth factor for multiple aromatic auxotrophs. J Bacteriol. 1967 Jan;93(1):502–503. doi: 10.1128/jb.93.1.502-503.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cox G. B., Gibson F., Pittard J. Mutant strains of Escherichia coli K-12 unable to form ubiquinone. J Bacteriol. 1968 May;95(5):1591–1598. doi: 10.1128/jb.95.5.1591-1598.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Doy C. H., Brown K. D. Control of aromatic biosynthesis: the multiplicity of 7-phospho-2-oxo-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating) in Escherichia coli W. Biochim Biophys Acta. 1965 Jul 8;104(2):377–389. doi: 10.1016/0304-4165(65)90343-0. [DOI] [PubMed] [Google Scholar]
- Gibson F., Pittard J. Pathways of biosynthesis of aromatic amino acids and vitamins and their control in microorganisms. Bacteriol Rev. 1968 Dec;32(4 Pt 2):465–492. [PMC free article] [PubMed] [Google Scholar]
- Huang M., Pittard J. Genetic analysis of mutant strains of Escherichia coli requiring p-aminobenzoic acid for growth. J Bacteriol. 1967 Jun;93(6):1938–1942. doi: 10.1128/jb.93.6.1938-1942.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
- MONOD J., COHEN-BAZIRE G., COHN M. Sur la biosynthèse de la beta-galactosidase (lactase) chez Escherichia coli; la spécificité de l'induction. Biochim Biophys Acta. 1951 Nov;7(4):585–599. doi: 10.1016/0006-3002(51)90072-8. [DOI] [PubMed] [Google Scholar]
- Pittard J., Camakaris J., Wallace B. J. Inhibition of 3-deoxy-d-arabinoheptulosonic acid-7-phosphate synthetase (trp) in Escherichia coli. J Bacteriol. 1969 Mar;97(3):1242–1247. doi: 10.1128/jb.97.3.1242-1247.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pittard J., Wallace B. J. Distribution and function of genes concerned with aromatic biosynthesis in Escherichia coli. J Bacteriol. 1966 Apr;91(4):1494–1508. doi: 10.1128/jb.91.4.1494-1508.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SMITH L. C., RAVEL J. M., LAX S. R., SHIVE W. The control of 3-deoxy-D-arabino-heptulosonic acid 7-phosphate synthesis by phenylalanine and tyrosine. J Biol Chem. 1962 Nov;237:3566–3570. [PubMed] [Google Scholar]
- Wallace B. J., Pittard J. Chromatography of 3-deoxy-D-arabinoheptulosonic acid-7-phosphate synthetase (trp) on diethylaminoethyl cellulose: a correction. J Bacteriol. 1967 Oct;94(4):1279–1280. doi: 10.1128/jb.94.4.1279-1280.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wallace B. J., Pittard J. Genetic and biochemical analysis of the isoenzymes concerned in the first reaction of aromatic biosynthesis in Escherichia coli. J Bacteriol. 1967 Jan;93(1):237–244. doi: 10.1128/jb.93.1.237-244.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wallace B. J., Pittard J. Regulator gene controlling enzymes concerned in tyrosine biosynthesis in Escherichia coli. J Bacteriol. 1969 Mar;97(3):1234–1241. doi: 10.1128/jb.97.3.1234-1241.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]