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. 1969 Sep;99(3):757–763. doi: 10.1128/jb.99.3.757-763.1969

Origin and Sequence of Chromosome Replication in Neisseria meningitidis: Influence of a Genetic Factor Determining Competence

Kaare Jyssum 1
PMCID: PMC250091  PMID: 4984175

Abstract

Chromosome replication in Neisseria meningitidis was examined by enumerating mutants induced by nitrosoguanidine during synchronous replication after release from prolonged chloramphenicol inhibition. Clear maxima of mutagenesis were observed at certain times. These times were different for seven individual markers. At a definite time after the first maximum, there was a second one. The intervals between successive maxima were identical for all markers in each experiment. This permitted the construction of replication maps which were in general agreement with mapping based on marker frequency analysis by use of a transformation system. Comparison of replication in genetically competent and genetically incompetent variants substantiated the previous assumption that the change from genetic competence to genetic incompetence in this strain results in a change in the replication origin as well as in the direction of replication.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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