Skip to main content
NCBI home page
Journal of Bacteriology logoLink to Journal of Bacteriology
. 1969 Nov;100(2):745–750. doi: 10.1128/jb.100.2.745-750.1969

Immunity to Staphylococcal Infection in Mice: Effect of Living Versus Killed Vaccine, Role of Circulating Antibody, and Induction of Protection-Inducing Antigen(s) In Vitro

Richard D Ekstedt a, Kosaku Yoshida a,1
PMCID: PMC250153  PMID: 5354944

Abstract

Mice immunized by sublethal doses of living Staphylococcus aureus strains other than the Smith diffuse strain were significantly more resistant to challenge with the Smith diffuse strain than animals immunized with heat-killed organisms. The increased resistance observed was shown, by appropriate passive protection experiments with immune mouse sera, to be due to circulating antibody, probably of the IgM class. In addition, it was observed that strains of S. aureus other than the Smith diffuse strain, when cultured in a modified Staphylococcus 110 broth but not in Brain Heart Infusion, were capable of absorbing protective antibody from hyperimmune rabbit antiserum.

Full text

PDF
745

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cluff L. E. Cellular reactions in the pathogenesis of staphylococcal infections. Ann N Y Acad Sci. 1965 Jul 23;128(1):214–230. doi: 10.1111/j.1749-6632.1965.tb11640.x. [DOI] [PubMed] [Google Scholar]
  2. ELEK S. D., CONEN P. E. The virulence of Staphylococcus pyogenes for man; a study of the problems of wound infection. Br J Exp Pathol. 1957 Dec;38(6):573–586. [PMC free article] [PubMed] [Google Scholar]
  3. Ekstedt R. D. Mechanisms of resistance to staphylococcal infection: natural and acquired. Ann N Y Acad Sci. 1965 Jul 23;128(1):301–334. doi: 10.1111/j.1749-6632.1965.tb11646.x. [DOI] [PubMed] [Google Scholar]
  4. HUNT G. A., MOSES A. J. Acute infection of mice with Smith strain of Staphylococcus aureus. Science. 1958 Dec 19;128(3338):1574–1575. doi: 10.1126/science.128.3338.1574. [DOI] [PubMed] [Google Scholar]
  5. KOENIG M. G., MELLY M. A., ROGERS D. E. Factors relating to the virulence of Staphylococci. II. Observations on four mouse-pathogenic strains. J Exp Med. 1962 Nov 1;116:589–599. doi: 10.1084/jem.116.5.589. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. MORSE S. I. Isolation and properties of a surface antigen of Staphylococcus aureus. J Exp Med. 1962 Feb 1;115:295–311. doi: 10.1084/jem.115.2.295. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. UHR J. W. THE HETEROGENEITY OF THE IMMUNE RESPONSE. Science. 1964 Jul 31;145(3631):457–464. doi: 10.1126/science.145.3631.457. [DOI] [PubMed] [Google Scholar]
  8. Yoshida K., Ekstedt R. D. Antibody response to Staphylococcus aureus in rabbits: sequence of immunoglobulin synthesis and its correlation with passive protection in mice. J Bacteriol. 1968 Nov;96(5):1540–1545. doi: 10.1128/jb.96.5.1540-1545.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Yoshida K., Ekstedt R. D. Relation of mucoid growth of Staphylococcus aureus to clumping factor reaction, morphology in serum-soft agar, and virulence. J Bacteriol. 1968 Oct;96(4):902–908. doi: 10.1128/jb.96.4.902-908.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Bacteriology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES