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. 1969 Nov;100(2):956–961. doi: 10.1128/jb.100.2.956-961.1969

Inhibitor-Induced Shift-Downs in Escherichia coli

Ross N Nazar 1, J Tze-Fei Wong 1
PMCID: PMC250180  PMID: 4901367

Abstract

A shift-down response in Escherichia coli cells has been brought about by moderate concentrations of azide or cyanide. Early events of the response included a preferential inhibition of ribonucleic acid relative to deoxyribonucleic acid synthesis, a degradation of polyribosomes, and an inhibition of protein synthesis followed by a transient relief. These changes were entirely comparable to those observed with nutrient-induced shift-downs. The influences of various nutrient supplements on an azide shift-down were examined, and methionine was found to relieve effectively the inhibition of ribonucleic acid synthesis in some strains of cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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