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Annals of The Royal College of Surgeons of England logoLink to Annals of The Royal College of Surgeons of England
. 1995 May;77(3):168–173.

Peptic ulcers can now be cured without operation.

J H Baron 1
PMCID: PMC2502085  PMID: 7598412

Abstract

Duodenum exposed to above threshold gastric acid secretion may ulcerate if infected with Helicobacter pylori. Duodenal ulcers can be healed by suppressing acid secretion medically or surgically; their recurrence can be prevented by lifelong antisecretory drugs or by an elective vagotomy. However, duodenal and gastric ulcers can now be healed, and recurrence prevented, without operation by eradication of H. pylori.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baron J. H. The discovery of gastric acid. Gastroenterology. 1979 May;76(5 Pt 1):1056–1064. [PubMed] [Google Scholar]
  2. Blaser M. J. Hypotheses on the pathogenesis and natural history of Helicobacter pylori-induced inflammation. Gastroenterology. 1992 Feb;102(2):720–727. doi: 10.1016/0016-5085(92)90126-j. [DOI] [PubMed] [Google Scholar]
  3. Graham D. Y., Go M. F. Helicobacter pylori: current status. Gastroenterology. 1993 Jul;105(1):279–282. doi: 10.1016/0016-5085(93)90038-e. [DOI] [PubMed] [Google Scholar]
  4. Jones D. B., Howden C. W., Burget D. W., Kerr G. D., Hunt R. H. Acid suppression in duodenal ulcer: a meta-analysis to define optimal dosing with antisecretory drugs. Gut. 1987 Sep;28(9):1120–1127. doi: 10.1136/gut.28.9.1120. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Labenz J., Börsch G. Evidence for the essential role of Helicobacter pylori in gastric ulcer disease. Gut. 1994 Jan;35(1):19–22. doi: 10.1136/gut.35.1.19. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Logan R. P., Gummett P. A., Misiewicz J. J., Karim Q. N., Walker M. M., Baron J. H. One week's anti-Helicobacter pylori treatment for duodenal ulcer. Gut. 1994 Jan;35(1):15–18. doi: 10.1136/gut.35.1.15. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Logan R. P., Gummett P. A., Schaufelberger H. D., Greaves R. R., Mendelson G. M., Walker M. M., Thomas P. H., Baron J. H., Misiewicz J. J. Eradication of Helicobacter pylori with clarithromycin and omeprazole. Gut. 1994 Mar;35(3):323–326. doi: 10.1136/gut.35.3.323. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Marshall B. J., McGechie D. B., Rogers P. A., Glancy R. J. Pyloric Campylobacter infection and gastroduodenal disease. Med J Aust. 1985 Apr 15;142(8):439–444. doi: 10.5694/j.1326-5377.1985.tb113444.x. [DOI] [PubMed] [Google Scholar]
  9. Rauws E. A., Tytgat G. N. Cure of duodenal ulcer associated with eradication of Helicobacter pylori. Lancet. 1990 May 26;335(8700):1233–1235. doi: 10.1016/0140-6736(90)91301-p. [DOI] [PubMed] [Google Scholar]
  10. Wyatt J. I., Rathbone B. J., Dixon M. F., Heatley R. V. Campylobacter pyloridis and acid induced gastric metaplasia in the pathogenesis of duodenitis. J Clin Pathol. 1987 Aug;40(8):841–848. doi: 10.1136/jcp.40.8.841. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. el-Omar E., Penman I., Dorrian C. A., Ardill J. E., McColl K. E. Eradicating Helicobacter pylori infection lowers gastrin mediated acid secretion by two thirds in patients with duodenal ulcer. Gut. 1993 Aug;34(8):1060–1065. doi: 10.1136/gut.34.8.1060. [DOI] [PMC free article] [PubMed] [Google Scholar]

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