Abstract
Cell-free extracts of Neurospora crassa mycelium catalyze the methylation of l-histidine to form hercynine (histidine betaine). The partially methylated compounds, α-N-methyl-l-histidine and α-N,N-dimethyl-l-histidine, are also methylated by the same enzyme preparation to form hercynine. All three methylation reactions are stimulated by the addition of S-adenosylmethionine.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ASKARI A., MELVILLE D. B. The reaction sequence in ergothioneine biosynthesis: hercynine as an intermediate. J Biol Chem. 1962 May;237:1615–1618. [PubMed] [Google Scholar]
- GENGHOF D. S., INAMINE E., KOVALENKO V., MELVILLE D. B. Ergothioneine in microorganisms. J Biol Chem. 1956 Nov;223(1):9–17. [PubMed] [Google Scholar]
- GENGHOF D. S., VANDAMME O. BIOSYNTHESIS OF ERGOTHIONEINE AND HERCYNINE BY MYCOBACTERIA. J Bacteriol. 1964 Apr;87:852–862. doi: 10.1128/jb.87.4.852-862.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Genghof D. S., Van Damme O. Biosynthesis of ergothioneine from endogenous hercynine in Mycobacterium smegmatis. J Bacteriol. 1968 Feb;95(2):340–344. doi: 10.1128/jb.95.2.340-344.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MELVILLE D. B., EICH S., LUDWIG M. L. The biosynthesis of ergothioneine. J Biol Chem. 1957 Feb;224(2):871–877. [PubMed] [Google Scholar]
- MELVILLE D. B., LUDWIG M. L., INAMINE E., RACHELE J. R. Transmethylation in the biosynthesis of ergothionelne. J Biol Chem. 1959 May;234(5):1195–1198. [PubMed] [Google Scholar]
- Reinhold V. N., Ishikawa Y., Melville D. B. Synthesis of alpha-N-methylated histidines. J Med Chem. 1968 Mar;11(2):258–260. doi: 10.1021/jm00308a014. [DOI] [PubMed] [Google Scholar]
- Scarborough G. A., Nyc J. F. Properties of a phosphatidylmonomethylethanolamine N-methyl-transferase from Neurospora crassa. Biochim Biophys Acta. 1967 Sep 12;146(1):111–119. doi: 10.1016/0005-2744(67)90077-0. [DOI] [PubMed] [Google Scholar]