Table 5.

Physiological data for CA1 responses to Schaffer collateral stimulation

Parameter	Wild-types	Transgenics
Maximal input–output slope (mV/μA)	3.2 ± 0.4	4.7 ± 0.6
(wt n = 15; trsg n = 17)
Current for maximum response (μA)	112.7 ± 9.6	104.2 ± 10.0
(wt n = 15; trsg n = 19)
Current for minimum response (μA)	30.7 ± 3.6	28.3 ± 2.4
(wt n = 15; trsg n = 19)
Maximum spike amplitude (mV)	13.0 ± 1.0	12.0 ± 1.1
(wt n = 15; trsg n = 20)
% change, 20 ms paired pulse	91.7 ± 12.4	159.7 ± 19.0*
(wt n = 13; trsg n = 18)
% change, 40 ms paired pulse	162.6 ± 15.6	204.3 ± 32.0
(wt n = 14; trsg n = 16)
% change, STP†	332.1 ± 51.3	269.6 ± 37.0
(wt n = 7; trsg n = 11)
% change, LTP†	178.7 ± 9.7	213.6 ± 19.8
(wt n = 7; trsg n = 6)
Potentiation in BDNF transgenic mice (wild-type mice all exhibited LTP and no spreading depression)
	STP	LTP
All experiments	228.2 ± 41.9	162.1 ± 19.6
(n = 13)
Experiments with no spreading depression	269.6 ± 37.1	160.6 ± 18.4
(n = 11)
Experiments with LTP	316.1 ± 51.5	214.1 ± 20.1
(n = 7)
Experiments with LTP and no spreading depression	322.8 ± 160.4	203.2 ± 20.0
(n = 6)

Data expressed as means ± S.E.M. Transgenic values which are significantly different than wild-type values are indicated by *. Not all slices were measured for all parameters; therefore the number of slices used for wild-types (wt) and transgenics (trsg) is included. Full statistics are included in the Results section, and a description of the measurements is included in the Experimental Procedures.

^†Experiments with no spreading depression.