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. 1988 Jan;62(1):346–348. doi: 10.1128/jvi.62.1.346-348.1988

Suppression of RNA synthesis by a specific antiviral activity in Sindbis virus-infected Aedes albopictus cells.

L D Condreay 1, D T Brown 1
PMCID: PMC250536  PMID: 2824854

Abstract

An antiviral protein is released by mosquito cells persistently infected with Sindbis virus. Differences in both sensitivity to and production of this virus-specific activity were apparent in three independently produced Aedes albopictus cell lines. This activity inhibits total viral RNA synthesis in a time-dependent manner. The antiviral effect is maximally realized when cells are treated with the activity 48 h before infections. These data suggest that the antiviral activity induces an antiviral state in treated cells which prevents the formation or efficient function of viral RNA-synthesizing complexes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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