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. 1989 May;63(5):2352–2356. doi: 10.1128/jvi.63.5.2352-2356.1989

Alterations in the structure of new and old forms of simian virus 40 large T antigen (T) defined by age-dependent epitope changes: new T is the same as ATPase-active T.

L C Tack 1, J H Wright 1, E G Gurney 1
PMCID: PMC250656  PMID: 2467995

Abstract

The reactivity of simian virus 40 large T antigen labeled under pulse-chase conditions towards 22 antibodies was measured. Changes in epitope reactivity occurred in several domains of T as it matured, defining major structural alterations that distinguished mature from new molecules. New T reacted best with the same antibodies that bind and inhibit ATPase-active T. These antibodies thus can distinguish new T as a distinct structural and functional form.

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Selected References

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