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. 1989 May;63(5):2385–2387. doi: 10.1128/jvi.63.5.2385-2387.1989

Resistance to foot-and-mouth disease virus mediated by trans-acting cellular products.

J C de la Torre 1, S de la Luna 1, J Diez 1, E Domingo 1
PMCID: PMC250663  PMID: 2539526

Abstract

Upon serial passage of BHK-21 cells persistently infected with foot-and-mouth disease virus (FMDV) C-S8c1, cells with increased resistance to the virus were selected (J. C. de la Torre, E. Martinez-Salas, J. Diez, and E. Domingo, J. Virol. 63:59-63, 1989). Two highly resistant cell clones, 74A11 and 74D12, were transformed to puromycin resistance (Purr) and were fused to BHK-21 cells transformed to neomycin resistance (Neor). The hybrid Neor Purr cells showed the specific resistance to FMDV C-S8c1 characteristic of clones 74A11 and 74D12. The results suggest that resistance to FMDV C-S8c1 is mediated by trans-acting cellular products. The possibility of engineering constitutive resistance to FMDV is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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