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. 1989 May;63(5):2411–2414. doi: 10.1128/jvi.63.5.2411-2414.1989

Susceptibility to raf and raf/myc retroviruses is governed by different genetic loci.

S P Klinken 1, J W Hartley 1, T N Fredrickson 1, U R Rapp 1, H C Morse 3rd 1
PMCID: PMC250669  PMID: 2539530

Abstract

The susceptibility to tumors induced by raf and raf/myc retroviruses was investigated in BALB/c, C57BL/6, (BALB/c x C57BL/6)F1 and (BALB/c x C57BL/6) backcross mice. Newborn mice were susceptible to neoplasms generated by both viruses, but resistance to raf-induced leukemia developed rapidly in all mice as they matured. Older C57BL/6 mice were also resistant to raf/myc lymphomas, whereas BALB/c mice remained susceptible to the virus at all ages, indicating that different genes control susceptibility to raf and raf/myc tumors. From these data and the susceptibility of C x B recombinant inbred strains, it appears that very few genes (perhaps even a single gene) may govern susceptibility to raf/myc lymphomas and that resistance is the dominant trait.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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