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. 1989 Jun;63(6):2534–2542. doi: 10.1128/jvi.63.6.2534-2542.1989

Structure of the Marek's disease virus BamHI-H gene family: genes of putative importance for tumor induction.

G Bradley 1, M Hayashi 1, G Lancz 1, A Tanaka 1, M Nonoyama 1
PMCID: PMC250719  PMID: 2542569

Abstract

The BamHI H fragment of Marek's disease virus (MDV), which has been hypothesized to contain a tumor-inducing gene, was partially sequenced and analyzed for transcriptional activity. Transcription of several RNAs was found to initiate within BamHI-H, with the major transcripts initiating on either side of a putative MDV origin of lytic replication. A 1.8-kilobase gene family found to be produced only by pathogenic MDV was detected, and its transcription map was produced. It is hypothesized that the 1.8-kilobase gene family is directly associated with the tumorigenic potential of MDV.

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